Type Of Receptor Cell Present On The Surface Of Neural Stem Cell May Help In Entry Of Zika Virus: Researcher Hypothesized New Thought Over Zika

Overview

• Post By : Kumar Jeetendra


• Source: Cell Press


• Date: 05 Apr,2016

Researcher recently hypothesized new thought over Zika virus infection which explores concepts over Zika and says type of receptor cell named “AXL surface receptor” mainly involve in Cell division is highly present on the surface of neural stem cell but surprisingly abscent over developing neuron, play a role in attracting Zika to enter for infection.

According to report the neural stem cells that express AXL are only present during the second trimester of pregnancy. These cells, called radial glial cells, give rise to the variety of cell types (e.g., neurons and astrocytes) that help build the cerebral cortex.AXL also expressed by retinal stem cells.

According to researcher,

"While by no means a full explanation, we believe that the expression of AXL by these cell types is an important clue for how the Zika virus is able to produce such devastating cases of microcephaly, and it fits very nicely with the evidence that's available," says senior study author Arnold Kriegstein, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. "AXL isn't the only receptor that's been linked with Zika infection, so next we need to move from 'guilt by association' and demonstrate that blocking this specific receptor can prevent infection.".

The concern research recently appears in Cell press and supported by the National Institutes of Health and the Damon Runyon Cancer Research Foundation.

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Story Source: Cell Press

Journal References:

Nowakowski et al. Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor. Cell Stem Cell, 2016 DOI: 10.1016/j.stem.2016.03.012