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Researcher from Chemical and Bimolecular Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST) developed a type of bio-refinery system for generating number of non natural polymers by using natural sources. The concern study appears online in Nature Biotechnology on March 7, 2016.
The team of researcher used non natural biomass which can replace petrochemical raw materials to develop number of useful full chemicals,bio-plastics,petrolium based end products which include,lubricants,paints,bio-plastics etc.
The bio-refinery system is based on metabolically engineered principle which develop type of strain of micro-organism which is used to synthesizing non natural polymers and succeeded to synthesize a type of co-polymer named: “PLGA” (Polylactate Co-glycol ate) which biodegradable and non toxic and could be used in different Biochemical and Bio-medical purposes.
According to report the team of researcher previously developed recombinant E. coli producing PLGA by using the glyoxylate shunt pathway for the generation of glycolate from glucose, which was disclosed in their patents KR10-1575585-0000 (filing date of March 11, 2011), US08883463 and JP5820363.
According to Pf.Sang Yup Lee, lead author and head of team of researcher,
"We presented important findings that non-natural polymers, such as PLGA which is commonly used for drug delivery or biomedical devices, were produced by a metabolically engineered gut bacterium. Our research is meaningful in that it proposes a platform strategy in metabolic engineering, which can be further utilized in the development of numerous non-natural, useful polymers."
Note: The above story is for information purposes for more information go through original story source.
Story source: The Korea Advanced Institute of Science and Technology (KAIST)
Journal References:
So Young Choi, Si Jae Park, Won Jun Kim, Jung Eun Yang, Hyuk Lee, Jihoon Shin, Sang Yup Lee. One-step fermentative production of poly (lactate-co-glycolate) from carbohydrates in Escherichia coli. Nature Biotechnology, 2016; DOI: 10.1038/nbt.3485
