what is cytolethal distending toxin

Cytolethal distending toxins (CDTs) are a group of heterotrimeric toxins synthesized by specific gram-negative bacteria, which exhibit DNase activity. The aforementioned toxins induce G2/M cell cycle arrest in particular mammalian cell lines, resulting in the formation of larger or distended cells, which are commonly associated with these toxins. Cytolethal distending toxins are categorized as AB …