Hot stage optical microscopy as an analytical tool to understand solid state changes in particle Characterization Kumar Jeetendra | May 5, 2020 When drug crystals are heated they undergo changes that can be observed under a microscope. Characteristics that can be analyzed under a microscope include melting point, melting range, crystal nucleation, crystal growth, crystal transformations and more. For example, under a microscope it is easy to see when a solid melts or how crystals nucleate and …