Possible connect to brain irritation may clarify the association among MS and exhaustion Kumar Jeetendra | August 27, 2020 As much as 60 percent of individuals with multiple sclerosis (MS) report that fatigue is that the disease’s most distressing symptom. And fatigue remains among MS’s puzzles — despite its incidence and significance, the root cause of this symptom remains unclear. In a study published in Neurology Neuroimmunology & Neuroinflammation, investigators from Brigham and Women’s …
Lupin gets USFDA gesture to showcase drug for treating backsliding various sclerosis Kumar Jeetendra | October 6, 2020 The company has received approval from the United States Food and Drug Administration (USFDA) to advertise its own Dimethyl Fumarate delayed-release capsules in the strengths of 120 mg and 240 mg, Lupin said in a statement. The item is a generic version of Biogen Inc”s Tecfidera delayed-release capsules at the same strengths, it added. The …
Study gives conceivable clarification to reformist course of different sclerosis in mice Kumar Jeetendra | October 17, 2020 People with multiple sclerosis (MS) gradually develop increasing functional impairment. Researchers at Karolinska Institutet in Sweden have found a possible explanation for the progressive course of this disease in mice and how it can be reversed. The analysis, which is published in Science Immunology, can prove beneficial to future treatments. MS is a chronic inflammatory …
Trial ALS drug shows potential to drag out patient endurance Kumar Jeetendra | October 18, 2020 An experimental medicine that was recently shown to slow the progression of the neurodegenerative disease amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, has now demonstrated the capacity to also prolong patient survival. The findings come from a clinical trial conducted by investigators at the Sean M. Healey & AMG Center for ALS at Massachusetts …
Myeloid cells can smother insusceptible reaction, advance cerebrum metastasis Kumar Jeetendra | October 28, 2020 Scientists have long thought that the brain protects itself from an aggressive immune response to keep inflammation down. However, that evolutionary management may work against it when a cancer cell tries to spread to the brain, researchers at the University of Notre Dame have found. In recently published research in the journal Cell, researchers showed …
Free radicals might be significant for the brain to stay versatile Kumar Jeetendra | December 6, 2020 Reactive oxygen molecules, also known as”free radicals”, are generally considered dangerous. Researchers from the German Center for Neurodegenerative Diseases (DZNE) and the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden published the findings in the journal Cell Stem Cell. The researchers focused on the”hippocampus”, a brain region that is regarded as the control center …
Gene therapy can viably treat mice with tuberous sclerosis complex, shows study Kumar Jeetendra | January 9, 2021 Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in several organs of the body, have limited treatment choices. A team led by investigators at Massachusetts General Hospital (MGH) has shown that gene therapy can effectively treat mice that express one of the mutated genes that cause the disease. …
Analysts recognize interface among ALS and collection of DNA-RNA hybrids in the genome Kumar Jeetendra | January 13, 2021 Researchers from the University of Seville and the University of Pavia have identified a connection between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of …
Scientists use genetics to recognize likely drugs for early administration of COVID-19 Kumar Jeetendra | April 12, 2021 A new study using human genetics indicates researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine at March 2021. The purpose is to identify present drugs, either FDA-approved or in clinical development for other conditions, that can …
Small molecule drug can weaken the triggers of neuroinflammation, preclinical review shows Kumar Jeetendra | September 24, 2021 Neuroinflammation may cause worse outcomes in cases of stroke, injuries to the brain or injury, and can increase the severity of neurodegenerative diseases such as ALS, Parkinson’s, or Alzheimer’s. This suggests that reducing neuroinflammation might be an exciting new method to treat neurological disorders and neuropathic pain caused by neuroinflammation. In a preclinical study , …
