Pharmaceutical Analysis: What effect does particle size have on solubility? Kumar Jeetendra | February 10, 2023 In the pharmaceutical industry, particle size is a key factor since it affects surface area and porosity, which in turn affects a drug’s bioavailability, effectiveness, and shelf life. Particle size is therefore examined in the creation of new active medicinal components as well as in quality control (APIs). In fact, while assessing novel medications, particle …