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It was well known that food having high fat content play great role in causing many type of cancer but now Researcher from Whitehead Institute for Biomedical Research recently describe how does high fat content cells makes cells of intestinal lining more sensitive for cancer. The concern study recently appears in Nature.
The scientists did study over mice and as a results it shows diet having high fat contents promotes growth and productivity of intestinal stem cells and urge other cells to behave like stem cells which itself grows and promotes tumors. "Not only does the high-fat diet change the biology of stem cells, it also changes the biology of non-stem-cell populations, which collectively leads to an increase in tumor formation," says Yilmaz, who is a Koch Institute member and a gastrointestinal pathologist at Massachusetts General Hospital and lead author of this research.
"We wanted to understand how a long-term high-fat diet influences the biology of stem cells, and how such diet-induced changes that occur in stem cells impact tumor initiation in the intestine," Yilmaz says. Under research examination scientist working over two mice samples they fed mice over 12 month and gave one mice high fat compare to other one. At the result mice having high fat content develop 20 to 30 percent more body mass and developed more tumors than mice having normal diet.
Note: The above study is for information purposes for more information go through original story source.
Journal References
Semir Beyaz, Miyeko D. Mana, Jatin Roper, Dmitriy Kedrin, Assieh Saadatpour, Sue-Jean Hong, Khristian E. Bauer-Rowe, Michael E. Xifaras, Adam Akkad, Erika Arias, Luca Pinello, Yarden Katz, Shweta Shinagare, Monther Abu-Remaileh, Maria M. Mihaylova, Dudley W. Lamming, Rizkullah Dogum, Guoji Guo, George W. Bell, Martin Selig, G. Petur Nielsen, Nitin Gupta, Cristina R. Ferrone, Vikram Deshpande, Guo-Cheng Yuan, Stuart H. Orkin, David M. Sabatini, Ömer H. Yilmaz. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature, 2016; 531 (7592): 53 DOI: 10.1038/nature17173
