Where does the krebs cycle take place : All you need to know

Where does the krebs cycle take place : All you need to know


  • Post By : Kumar Jeetendra

  • Source:

  • Date: 13 Feb,2024

In the mitochondria of eukaryotic cells is a metabolic mechanism known as the Krebs Cycle, which is also known as the TCA cycle or citric acid cycle.

What follows is some information pertinent to the location of its occurrence.

Where does the Krebs Cycle occur?:

Within the mitochondria of eukaryotic cells is where the Krebs cycle occurs in its majority, in the matrix of mitochondria. Because they generate energy via Kreb’s cycles and oxidative phosphorylation, these organelles are called mitochondria. The Structure of


In addition to their outer membrane, mitochondria also have an inner membrane that encases the matrix within.

How Enzymes Work:

As an example, ATP is produced through a series of enzymatic events using acetyl-CoA, which is produced by several metabolic pathways such as beta-oxidation and glycolysis. NADH and FADH2 are then utilized as reducing equivalents and electron carriers, respectively. Coenzyme A (CoA) connected to an acetyl group undergoes a sequence of conversions to citrate in these reactions, which in turn release carbon dioxide and produce reducing equivalents and precursors for ATP synthesis.

Key Steps:

  1. Citrate synthase initiates this pathway with condensation reaction between acetyl-CoA and oxaloacetate forming citrate.
  2. Moreover, during sequential steps, NADH, FADH2 and GTP generation products like guanosine triphosphate occur when citrates oxidize back to reform oxaloacetate.
  3. Notable events include transformation from Isocitrate to fumarate via α-ketoglutarate to succinyl CoA through malate formation before subsequent regeneration of oxaloacetate.

Role in Cellular Respiration:

  1. ATP which is the universal cellular energy currency is provided by glucose oxidation together with other organic compounds involved in cellular respiration upon oxidation to give out energy.
  2. This process links glycolysis, which occurs in the cytoplasm, to oxidative phosphorylation, which takes place in the inner mitochondrial membrane because NADH and FADH2 donate electrons to the electron transport chain.

In summary, Krebs cycle is a fundamental process of cellular respiration that oxidizes acetyl-CoA from various metabolic pathways generating ATP and reducing equivalents; thus it happens within mitochondria matrix. In these eukaryotic cells, this cyclic pathway is important to generate energy and maintain cell function.

About Author