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Dear Readers, Welcome to the latest issue of The Magazine
What is involved in the mastery of cellular respiration? In simple terms, it means understanding how important the Krebs cycle is for generating energy during cellular respiration.
Mitochondrial matrix, the innermost compartment of mitochondria, known as energy hubs because they produce ATP; it is here that Krebs cycle occurs.
TCA or the Krebs cycle pathway is a central metabolic pathway burning different types of fuel molecules such as glucose, fatty acids and amino acids via acetyl-CoA to generate NADH, FADH2 and GTP/ATP which are high energy compounds.
Regulation by product inhibition, substrate availability and allostery characterize enzymes within it. Inhibitory effects on several enzymes in this pathway can be experienced when their level is high leading to decrease their activity due to ATP or NADH saturation.
The summary is that the Krebs cycle plays a significant role in cellular respiration as it provides a controlled oxidation mechanism for Acetyl-CoA and helps to store energy that will be used later on during ATP generation. Mastery of its intricate details therefore forms a basis for understanding cellular respiration as interplay between different aspects involved in cellular metabolism.