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Dear Readers, Welcome to the latest issue of The Magazine
Many breakthroughs characterize the world of genetics and explain to us the complex process of life. Every research has its targeted chromosomes, and some researchers have begun to focus on the Tub8 gene. Although Tub8 doesn’t enjoy the popular limelight of genes such as the P53 gene, Tub8 is necessary for functional aspects of cells and biological activities.
The Tub8 gene is a member of the tubulin gene family that, inter alia, encodes microtubule proteins. Microtubules are essential components of the cytoskeleton – an internal structural network of the cells which provides cells with their shape and supports them, among other functions. Microtubules are also vital for a number of processes such as cell division, intracellular movement, and motility. To put it in simple terms, without the proteins created by tubulin genes like Tub8, our cells might work but not effectively.
The Tub8 gene’s primary expression has been localized to cellular structures involved in mitosis, the equatorial division of cells. It means that it is quite important in cell division and tissue repair processes, perhaps more important in those areas containing quickly dividing stem cells and certain organs.
With respect to mitosis, the Tub8 gene encodes for a tubulin-like protein that is involved in the formation of spindle fibers. These are necessary structures in the segregation of daughter cells’ chromosomes during cell division. Errors in spindle fiber formation are implicated in chromosomal instability which is observed in many diseases including cancer.
Besides its involvement in cell division, the Tub8 gene has a role in the sub cellular organization as well. Microtubules constructed from tubulin proteins are actually constructs that act as highways within the cell and passenger molecules or organelles. This internal system of transportation ensures that the cells work properly, therefore any disruption of this system may result into a number of cellular dysfunctions.
The research on Tub8 gene is few and relatively new, however the prospects of this gene are of great interest to researchers. Other studies have started to support the idea that Tub8 mutations or Tub8 dysregulation may underlie developmental disorders and other diseases characterized by impaired cell division. Perhaps as we advance, the Tub8 gene ends up distinguishing itself as one of the prime candidates for gene therapy or perhaps even a treatment that reverses errors found during mitosis.
Taking into account the relation of tubulin proteins and cancer it could be possible to suggest Tub8 in the future settings of tumor cancer research. Certain tumours were already effectively treated with drugs that target microtubules, for example, taxanes. With clearer understandings of how Tub8 for example, interacts with microtubule patterns in the future, more refined strategies targeting this gene in cancer therapies can be introduced.
The significance of the Tub8 gene is not restricted to the paradigmatic functions of the cell. It acts as a gateway on genetic research as a whole, whereby knowing what each of the genes does could be helpful in developing better ways of diagnosing and treating different kinds of diseases. With the improving technology in understanding the human genome, other genes such as Tub8 may play an important role in treatment or prevention of genetic ailments and provide further insight into the pathology of diseases associated with abnormal cell proliferation and growth.
In addition, the investigation of the Tub8 gene also highlights the issue of stability of the architecture of cellular compartments. The maintenance of cell structure and function is governed by genes, and this context even the slightest perturbations can have drastic consequences on health therefore the genetic research should never cease.
Among all of these genes Tub8 gene does not noise directly but it should not be overlooked any time also. Tub8 contributes to the correct tubulin polymerization or understanding of its role in cellular division. Because of Tub8, our cells remain structurally firm and perform essential activities efficiently. Most likely, as understanding of the gene develops, it may have an even broader implementation in the therapy of many diseases and conditions, such as chromosomal instability or cancer.
Understanding genes such as Tub8 is also important for further research. So as we go along with the human genome project, an insertional gene such as the Tub8 gene, especially, will provide immense helpful information in the understanding of life as an entity and how the cells in our bodies system are kept healthy and active.
