SARS-CoV-2 hereditary changes may have made COVID-19 more infectious Kumar Jeetendra | October 31, 2020 A study involving over 5,000 COVID-19 patients in Houston finds the virus which causes the disease is accumulating genetic mutations, one of which may have made it longer infectious. According to the paper published in the peer reviewed journal mBIO, that mutation, known as D614G, is found in the spike protein that pries open our …
First enzyme driven biocatalytic creation of nucleic acid structure blocks Kumar Jeetendra | December 15, 2020 Researchers in TU Graz and acib succeed in the first enzyme-driven biocatalytic synthesis of lipoic acid building blocks. This facilitates the development of antiviral agents and RNA-based therapeutics. Because of this COVID 19 pandemic and the related intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is undergoing an enormous increase in …
Pig stem cells offer another approach to develop human organs for transplantation Kumar Jeetendra | December 18, 2020 In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly generated stem cells from cows, when injected into embryos, contributed to the growth of only the organ of interest (the embryonic …
FDA-endorsed COVID-19 medication should be utilized warily, says UC researcher Kumar Jeetendra | January 4, 2021 While the world has its eyes on vaccines to stop the spread of coronavirus, therapeutics continue to be necessary to treat hepatitis patients. One of these treatments, remdesivir, is the first and only antiviral agent of its type the U.S. Food and Drug Administration (FDA) has approved so far for COVID-19. Research at the University …
Altered lipids focus on the body’s endocannabinoid framework to control pain and inflammation Kumar Jeetendra | February 10, 2021 When modified using a process known as epoxidation, two naturally occurring lipids are converted to potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways which promote inflammation and pain, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much stronger effects than the molecules from which they are derived, which also modulate …
Study describes cisplatin-prompted hearing loss in pediatric cancer growth patients Kumar Jeetendra | February 14, 2021 Permanent hearing loss is a common side effect of the medicine, but until now, studies have been too little and too varied to accurately characterize this risk. Today in The Lancet Child & Adolescent Health, researchers at Children’s Hospital Los Angeles published results of the biggest analysis of cisplatin-induced hearing loss to date. The analysis …
Microorganisms utilize vile methodology to vanquish antibody that battle cystic fibrosis Kumar Jeetendra | February 28, 2021 University of Montana researchers and their partners have found a slimy strategy used by bacteria to conquer antibiotics and other medications used to combat infections afflicting individuals with cystic fibrosis. Cystic fibrosis is a life-threatening illness which causes persistent lung infections and limits an individual’s ability to breathe over time. A frequent strain of bacteria, …
Mosquito protein study could prompt therapeutics against dangerous viruses Kumar Jeetendra | March 11, 2021 The researchers found that AEG12 works by destabilizing the viral envelope, breaking its protective covering. Although the protein doesn’t affect viruses that don’t have an envelope, such as the ones that cause pink eye and bladder ailments, the findings could lead to therapeutics against viruses which affect millions of people around the world. The research …
CN Bio presents the PhysioMimix™ OOC Multi-Organ Microphysiological System Kumar Jeetendra | March 17, 2021 CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS. The next-generation system unites CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to …
Researcher find a gene mutation connected to schizophrenia Kumar Jeetendra | March 24, 2021 Researchers at The Feinstein Institutes for Medical Research, in collaboration with Columbia University, have identified a gene mutation that could result in schizophrenia, a chronic brain disease that affects nearly 1 percent of the planet’s inhabitants. The findings, published in today in Neuron, could lead to novel treatment strategies. The research group, headed by Todd …
Researchers describe the systems that manage embryonic stem cells Kumar Jeetendra | March 26, 2021 Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have clarified the mechanisms, unknown to date, included in maintaining embryonic stem cells in the best possible condition for their use in regenerative medicine. The results, published in Nature Communications, helps to find novel stem-cell therapies for …
Study uncovers molecular mechanisms of drug resistance in Mycobacterium tuberculosis Kumar Jeetendra | April 9, 2021 A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way by which Mycobacterium tuberculosis survives in iron-deficient states by using rubredoxin B, a protein by a rubredoxin family that play an essential role in adaptation to changing environmental conditions. The new study is part of …
