National consortium to examine the impacts of arising SARS-CoV-2 mutations Kumar Jeetendra | January 16, 2021 The’G2P-UK’ National Virology Consortium will study how mutations in the virus affect key outcomes like how transmissible it is, the seriousness of COVID-19 it causes, and the potency of vaccines and treatments. The Consortium will bring together leading virologists from 10 research institutions. They will work together with the COVID-19 Genomics UK (COG-UK) consortium, which …
Inflammation may add to the determination of C. diff disease, shows study Kumar Jeetendra | January 19, 2021 A new study from North Carolina State University indicates that the inflammation brought on by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and supplying nutrients that enable C. diff to thrive. C. diff is a bacterium that causes diarrhea, often with severe …
Research finds new proof about the systems controlling skin repair and regeneration Kumar Jeetendra | January 19, 2021 As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has discovered new evidence deep within the skin about the mechanisms controlling skin renewal and repair. Skin’s barrier function gives it the unique ability to fight winter woes and keep …
Putatively juvenile dendritic cells may actuate hearty resistant reactions in young children Kumar Jeetendra | January 20, 2021 A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers demonstrates that putatively immature dendritic cells found in young children are able to induce strong immune responses. Dendritic cells are a vital component of the innate immune system, which represents the body’s first line of defense against infectious agents and tumor cells. Their job is to trigger …
Scientists find uncommon hereditary disorder that influences the brain, heart and facial highlights Kumar Jeetendra | January 21, 2021 Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features. Named linkage-specific-deubiquitylation-deficiency-induced embryonic defects syndrome (LINKED), it is caused by a mutated version of the OTUD5 gene, which interferes with key molecular actions in embryo development. The findings indicate …
New upkeep treatment for AML shows solid advantage for patients Kumar Jeetendra | January 23, 2021 Patients with acute myeloid leukemia (AML), the most common form of leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance therapy, based on a randomized, international phase 3 clinical …
UC research group utilizes zebrafish to contemplate a quality change that causes intrinsic scoliosis Kumar Jeetendra | January 24, 2021 Popular in aquariums throughout the world, the zebrafish is native to South Asia. But here in a Cincinnati Children’s laboratory, the freshwater variant plays a vital role in scientific discovery. The patterning of the zebrafish’s spine gives the appearance of stripes; it is controlled by segmentation genes which function as a clock. Zinani is part …
World’s first completely reversible control of the circadian clock Kumar Jeetendra | January 26, 2021 The Nagoya University Institute of Transformative Bio-Molecules (WPI-ITbM) research team of Designated Associate Professor Tsuyoshi Hirota, Postdoctoral Fellow Simon Miller, Professor Kenichiro Itami and grad student Tsuyoshi Oshima (Research Fellowship for Young Scientists, JSPS), in collaboration with the team of Professor Ben Feringa and Postdoctoral Fellow Dušan Kolarski of Groningen University in the Netherlands, have …
Study shows why children of obese moms have inclination to create metabolic illnesses Kumar Jeetendra | January 27, 2021 A Brazilian study published in the journal Molecular Human Reproduction helps understand why overweight mothers often have children with a propensity to develop metabolic disease during their lifetime, according to previous research. According to the authors,”transgenerational transmission of metabolic disorders” may be associated with Mfn2 deficiency in the mother’s oocytes (immature eggs). Mfn2 refers to …
Sulforaphane draws out life expectancy and healthspan of C. elegans through insulin/IGF-1 flagging Kumar Jeetendra | February 4, 2021 Aging-US released”Sulforaphane boosts C. elegans longevity and healthspan through DAF- 16/DAF-2 insulin/IGF-1 signaling” which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its impact on healthspan and longevity are unclear. The writers used the C. elegans nematode version and fed the wildtype and 9 mutant strains ±sulforaphane. Sulforaphane increased the …
Gene panel test empowers exceptionally exact diagnosis of liposarcomas Kumar Jeetendra | February 5, 2021 Scientists have leveraged the latest advances in RNA technology and machine learning methods to develop a gene panel evaluation which allows for highly accurate diagnosis of the most frequent kinds of liposarcoma. The new assay is described in The Journal of Molecular Diagnosis, published by Elsevier. Liposarcomas are a type of malignant cancer that is …
Altered lipids focus on the body’s endocannabinoid framework to control pain and inflammation Kumar Jeetendra | February 10, 2021 When modified using a process known as epoxidation, two naturally occurring lipids are converted to potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways which promote inflammation and pain, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much stronger effects than the molecules from which they are derived, which also modulate …
