Sulforaphane draws out life expectancy and healthspan of C. elegans through insulin/IGF-1 flagging

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• Source: Aging-US


• Date: 04 Feb,2021

Aging-US released”Sulforaphane boosts C. elegans longevity and healthspan through DAF- 16/DAF-2 insulin/IGF-1 signaling” which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its impact on healthspan and longevity are unclear.

The writers used the C. elegans nematode version and fed the wildtype and 9 mutant strains ±sulforaphane.

Sulforaphane increased the lifespan and encouraged a health-related phenotype by increasing mobility, appetite and food intake and reducing lipofuscin accumulation.

This was correlated with increased nuclear translocation of the FOXO transcription factor homolog DAF-16. In turn, the target genes sod-3, mtl-1 and gst-4, known to improve stress resistance and lifespan, were upregulated.

They supply the foundation for a nutritional sulforaphane-enriched strategy for the promotion of healthy aging and disease prevention.

Dr. Ingrid Herr from The University of Heidelberg said,”The risk of cancer, cardiovascular disease, and neurodegeneration climbs dramatically later in life.”

Pak choy, which is one of the most widely consumed Brassica vegetables in Asian countries, have been reported to enhance antioxidant action in a cell-free system and apply anti-aging effects in the nematode Caenorhabditis elegans.

C. elegans is one of the most widely used models for aging research due to the short lifespan of approximately 4 months and highly conserved key aging-related signaling molecules.

Here, the authors asked if sulforaphane may influence the lifespan and healthspan of C. elegans.

They found that sulforaphane significantly extends the life span of C. elegans and delays age-related phenotype changes.

The study of wild-type C. elegans and 9 mutant strains revealed that sulforaphane inhibited DAF-2 insulin/insulin receptor signaling and thereby increased DAF-16 nuclear translocation, resulting in the expression of the sod-3, mtl-1 and gst-4 target genes, which are known mediators of longevity in C. elegans.

Our analysis provides a promising hint concerning the suitability of sulforaphane as a new anti-aging drug. Nevertheless, additional studies in invertebrates and mammalian model organisms are essential to expand our findings.”