Microorganisms in the lungs could impact lung cancer progression and prognosis Kumar Jeetendra | November 11, 2020 Bottom Line: Enrichment of the lungs with oral commensal microbes has been correlated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer. Journal in Which the research was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Leopoldo Segal, MD, director of the Lung Microbiome Program, …
Study uncovers a quality answerable for anthraquinone synthesis in plants Kumar Jeetendra | November 25, 2020 Anthraquinones are a class of naturally occurring chemicals prized for their medicinal properties, as well as for other programs, including ecologically friendly dyes. Despite broad interest, the mechanism by which plants produce them has remained shrouded in mystery until today. New work from an international group of scientists including Carnegie’s Sue Rhee shows a gene …
Skin may assist with foreseeing future heart issues Kumar Jeetendra | December 17, 2020 Our skin informs us when we have spent too much time in sunlight or when the dry air of winter has sucked away too much moisture. Now Jefferson researchers find that the skin may also foretell problems unrelated to the protective barrier. An international group of researchers headed by Jouni Uitto, MD, PhD, a Professor …
Another way to deal with distinguish genomic areas in our cerebrum that add to make us human Kumar Jeetendra | December 17, 2020 With just 1% gap, the human and chimpanzee protein-coding genomes are remarkably similar. Knowing the biological characteristics that make us human is a part of a fascinating and intensely debated line of study. The paper is printed in Science Advances. Gene expression, not gene arrangement To describe what sets human besides their ape relatives, researchers …
Researchers find out protein that adjusts gene interest to healthy nutrient stages in roundworms Kumar Jeetendra | December 23, 2020 Changing a fertilized egg into a fully functional adult is a complicated endeavor. Cells must split, move, and mature at specific times. Developmental genes control that process, turning on and off at a choreographed way. However, the environment affects development. They discovered a master switch developing worms use to pause growth when nutrients are scarce. …
Polygenic threat ratings from multi-populace information should enhance IBD predictions Kumar Jeetendra | December 25, 2020 Using genetic data from nearly 30,000 individuals, Mount Sinai researchers have assembled hazard scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The research was published in Gastroenterology on December 24. The researchers found that polygenic risk scores, …
Study famous how ecDNA fragments pressure gene amplification to generate drug resistance in cancer Kumar Jeetendra | December 26, 2020 Researchers headed by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the puzzle of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to create drug resistance in cancer. The study, published on December 23 in the journal Nature, provides new …
Researchers find out how shattered chromosomes make most cancers cells greater aggressive Kumar Jeetendra | December 27, 2020 Cancer is one of the world’s biggest health afflictions because, unlike some diseases, it’s a moving target, constantly evolving to evade and resist treatment. In a paper published in the December 23, 2020 online dilemma of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the …
Gene therapy can viably treat mice with tuberous sclerosis complex, shows study Kumar Jeetendra | January 9, 2021 Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in several organs of the body, have limited treatment choices. A team led by investigators at Massachusetts General Hospital (MGH) has shown that gene therapy can effectively treat mice that express one of the mutated genes that cause the disease. …
Biomarkers can foresee how hereditarily identical cells act distinctively under pressure Kumar Jeetendra | January 10, 2021 A set of biomarkers not traditionally associated with cell fate can accurately forecast how genetically identical cells behave differently under pressure, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually result in more predictable responses to pharmaceutical remedies. Groups of the same types of …
Boosting a characteristic cell cycle could bring down ventilator-related lung damage Kumar Jeetendra | January 12, 2021 An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is very likely to cause further lung damage. In a new study, scientists identified a molecule that’s produced by immune cells during mechanical ventilation to try to decrease …
Researchers develop insect sex pheromones in transgenic camelina plant for maintainable pest control Kumar Jeetendra | January 15, 2021 The camelina plant, a source of cooking oil for centuries, is on its way toward revolutionizing pest management in agriculture. Researchers at ISCA, Inc., a green agtech firm based in Riverside, Calif., and their collaborators in Sweden have “grown” insect sex pheromone precursors in genetically modified strains of camelina plants, creating a low-cost source of …
