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Researcher from Tufts University, Health Sciences Campus for the first time reprogrammed skin of Diabetic foot ulcer patients to embryonic-like cells and this induced pluripotent cells may provide hope for treating chronic wounds disease in future.
The concern research study recently appears online in advance of print in Cellular Reprogramming.
rnAccording to researcher,
"The results are encouraging. Unlike cells taken from healthy human skin, cells taken from wounds that don't heal — like diabetic foot ulcers — are difficult to grow and do not restore normal tissue function," said senior author on both studies, Jonathan Garlick, Ph.D., D.D.S., stem cell researcher at Tufts University School of Dental Medicine in Boston. "By pushing these diabetic wound cells back to this earliest, embryonic stage of development, we have "rebooted" them to a new starting point to hopefully make them into specific cell types that can heal wounds in patients suffering from non-healing wounds."
The work appears online in Wound repair. According to data about 29 million Americans suffering with diabetic disorders and generally diabetic foot ulcers are resistant to treatment. The concern immunotherapy may play an important role in treatment of wound patients.
Story source/Credit: Tufts University, Health Sciences Campus
Journal References:
Behzad Gerami-Naini, Avi Smith, Anna G. Maione, Olga Kashpur, Gianpaolo Carpinito, Aristides Veves, David J. Mooney, Jonathan A. Garlick. Generation of Induced Pluripotent Stem Cells from Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus. Cellular Reprogramming, 2016; DOI: 10.1089/cell.2015.0087
