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The water vapor or absorbent properties of pharmaceutical products like excipients, packaging films and drug formulations are acknowledged as key aspects that determine their storage stability, processing, and performance. In accordance with the US Pharmacopeia, moisture is not considered to be an impurity. However, the presence of water in a drug must be monitored and controlled as closely as is feasible. (USP general chapter 1241). Further, the moisture content affects crystallinity and influences storage modulus, permeability, density and melting point of pharmaceutical products. In particular to amorphous materials, moisture can significantly alter the glass transition temperature, and even initiate spontaneous transformation to the crystalline form. Additionally, water facilitates hydrolysis and induces drug degradation. Finally, water content is routinely used in determining the dry and solvent-free assay value of a drug substance.
For the above reasons, a rapid, highly- sensitive and automated method to study moisture sorption properties is desired.
Thus, the invention of the Dynamic Vapor Sorption (DVS) instrument by Surface Measurement Systems in the early 1990’s. Today, the DVS is widely used across numerous industries for investigating the Vapor sorption properties of solids, fibres, gels, particulates, and composite materials.
Utilizing the capabilities in Dynamic Vapor Sorption instrumentation, the characteristics of sorption by Vapor to be studied using API’s, excipients and final formulations tablets, capsules as well as packaging material. The sorption of water on these materials could be crucial in understanding the stability of materials and their performance.
To know more about how DVS technology could be applied to a wide range of pharmaceutical-related materials and challenges.
Click here to download.
For more information: https://www.surfacemeasurementsystems.com/
About DVS:
Dynamic Vapor Sorption (DVS) is a gravimetric technique that measures how quickly and how much of a solvent is absorbed by a sample: such as a dry powder absorbing water. It does this by varying the vapor concentration surrounding the sample and measuring the change in mass which this produces. Water vapor is most commonly used, but it is also possible to use a wide range of organic solvents.
Dynamic Vapor Sorption is a valued tool in laboratories all over the world, within R&D, from polymorphism and compound stability studies to bulk and surface sorption effects of water and organic vapors. It is a vital part of quality control analysis techniques for both scale-up and production, and can even be found within the packaging area, measuring efficacy, permeability, and the effects of humidity and temperature on the samples within the packaging.
