Polygenic threat ratings from multi-populace information should enhance IBD predictions Kumar Jeetendra | December 25, 2020 Using genetic data from nearly 30,000 individuals, Mount Sinai researchers have assembled hazard scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The research was published in Gastroenterology on December 24. The researchers found that polygenic risk scores, …
Study famous how ecDNA fragments pressure gene amplification to generate drug resistance in cancer Kumar Jeetendra | December 26, 2020 Researchers headed by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the puzzle of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to create drug resistance in cancer. The study, published on December 23 in the journal Nature, provides new …
Researchers find out how shattered chromosomes make most cancers cells greater aggressive Kumar Jeetendra | December 27, 2020 Cancer is one of the world’s biggest health afflictions because, unlike some diseases, it’s a moving target, constantly evolving to evade and resist treatment. In a paper published in the December 23, 2020 online dilemma of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the …
Analysts recognize interface among ALS and collection of DNA-RNA hybrids in the genome Kumar Jeetendra | January 13, 2021 Researchers from the University of Seville and the University of Pavia have identified a connection between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of …
Research finds new proof about the systems controlling skin repair and regeneration Kumar Jeetendra | January 19, 2021 As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has discovered new evidence deep within the skin about the mechanisms controlling skin renewal and repair. Skin’s barrier function gives it the unique ability to fight winter woes and keep …
Scientists find uncommon hereditary disorder that influences the brain, heart and facial highlights Kumar Jeetendra | January 21, 2021 Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features. Named linkage-specific-deubiquitylation-deficiency-induced embryonic defects syndrome (LINKED), it is caused by a mutated version of the OTUD5 gene, which interferes with key molecular actions in embryo development. The findings indicate …
Protein alteration adds to degeneration of neuronal populaces in Huntington’s infection Kumar Jeetendra | February 1, 2021 A study in which UB scientists have taken part states that alterations in the levels of one of those proteins, lamin B1, add to the degeneration of distinct brain neuronal populations in Huntington’s disease. Caused by a mutation in the huntingtin gene, this pathology features involuntary movements, cognitive deficit, and psychiatric disorders, and has no …
Retroviruses attacking the koala germline add to high malignant growth rates Kumar Jeetendra | February 26, 2021 Koalas are facing multiple ecological and health issues which threaten their survival. Together with habitat loss – accelerated by last year’s devastating bush fires — domestic dog attacks and road accidents, they suffer from fatal chlamydial infections and extremely high frequency of cancer. The results are reported in the journal Nature Communications. The koala retrovirus …
Genomic Data Commons offers the biggest asset in cancer genomics Kumar Jeetendra | February 27, 2021 The National Cancer Institute’s Genomic Data Commons (GDC), launched in 2016 by then-Vice President Joseph Biden and hosted at the University of Chicago, has become one of the largest and most widely used resources in cancer genomics, with over 3.3 petabytes of data from more than 65 jobs and more than 84,000 anonymized patient cases, …
Genomic surveillance can help recognize how SARS-CoV-2 spreads in care homes Kumar Jeetendra | March 4, 2021 Care homes are at high risk of experiencing outbreaks of COVID-19, the disease brought on by SARS-CoV-2. Older people and people affected by heart disease, respiratory disease and type 2 diabetes – all of which increase with age – are at greatest risk of severe disease and even death, which makes the care home population …
Bacteria residing within inside tumor cells can support malignant growth immunotherapy Kumar Jeetendra | March 22, 2021 Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. The study may also help clarify the connection between immunotherapy and the intestine microbiome, describing the findings of earlier research that the microbiome impacts the success of immunotherapy. Immunotherapy remedies of the last decade or so have dramatically improved healing …
FDA denies EUA for monoclonal antibody treatment bamlanivimab to treat patients with COVID Kumar Jeetendra | April 18, 2021 Now, the U.S. Food and Drug Administration revoked the emergency use authorization (EUA) that allowed for the investigational monoclonal antibody treatment bamlanivimab, when administered alone, to be utilized for treating mild-to-moderate COVID-19 in adults and certain pediatric patients. Based on its ongoing analysis of emerging scientific data, specifically the sustained increase of SARS-CoV-2 viral variants …
