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    Genomic

    New polygenic danger score to help foresee the chances of medications causing liver harm

    The ancient Romans studied the livers of sacrificial animals to read omens and create prophesies. Researchers at Tokyo Medical and Dental University (TMDU) and Takeda-CiRA program alongside a world-wide group of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the probability of medications causing liver damage. Adding new

    Molecular investigation of COVID-19’s subsequent wave shows freak infections connected to quick spread

    Molecular analysis of COVID-19’s powerful second wave in Houston — from May 12 to July 7 — shows that a mutated virus strain linked to higher transmission and infection rates than the coronavirus strains that caused Houston’s first wave. Gene sequencing results from 5,085 COVID-positive patients analyzed at Houston Methodist since early March show a

    Study uncovers a quality answerable for anthraquinone synthesis in plants

    Anthraquinones are a class of naturally occurring chemicals prized for their medicinal properties, as well as for other programs, including ecologically friendly dyes. Despite broad interest, the mechanism by which plants produce them has remained shrouded in mystery until today. New work from an international group of scientists including Carnegie’s Sue Rhee shows a gene

    ATCC presents new product with launch of SARS-CoV-2 external control unit

    The ready-to-run kit provides controls in the rapidly changing COVID-19 testing landscape as a workflow-optimized kit with complete genome coverage that is widely compatible with most commercial and laboratory-developed tests. Federal regulation requires that clinical laboratories assess the performance of their testing applications. This new ATCC kit is a practical, kitted solution clinical laboratories can

    Hematoxylin compounds can specifically kill CALR mutant cancer cells

    Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Researchers of the research team of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the

    IGC analysts get three out of six European Research Council grants

    Since the establishment of the European Research Council in 2008, the IGC has secured 17 of the competitive grants (7 Beginning, 8 Consolidator and two Advanced). In 2021, with the beginning of the new grants awarded this month, it will have ten active grants. The year of 2020 marks a total of 327 researchers chosen

    Study recognizes biomarker gene mark that demonstrates likely liver toxicity

    When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal research. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a couple of days while still

    Hematoxylin compounds can specifically kill CALR freak disease cells

    Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the

    Study clarifies the impact of getting old on hematopoietic stem cells

    By shifting mouse elderly hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was shown that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. On the other hand, the function of elderly HSCs failed to recover in the young bone marrow