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    Genetics

    Drug discovery pipeline to exploit transcription factors for cancer therapy

    Cancer is a major cause of death and among the most complicated challenges to contemporary medication. By employing cutting-edge technologies that precisely measure the effects of candidate targets and drugs on the fundamental process of transcription, the new start-up firm QUANTRO Therapeutics tries to radically change the precision and range of cell-based drug screening. QUANTRO’s

    Test mRNA-based COVID-19 immunization evokes defensive safe reactions in animals

    Two injections of this vaccine were enough to induce robust immunity, completely preventing SARS-CoV-2 infection in mice. MRNA-based vaccines are all attractive options for protecting against SARS-CoV-2 because they may be quickly designed and manufactured at a huge scale within weeks. Moreover, preclinical studies have shown that mRNA-based vaccines cause potent and broadly protective immune

    Custom smartwatch tracks sedate levels inside the body continuously

    Engineers in the UCLA Samueli School of Engineering and their colleagues at Stanford School of Medicine have demonstrated that drug levels inside the body is able to be tracked in real time using a custom smartwatch which assesses the compounds found in sweat. This wearable technology can be incorporated into a more personalized approach to

    Study recognizes new arrangement of performing multiple tasks taste cells

    Our mouths might be home to some recently discovered group of multi-tasking taste cells -;unlike most famous flavor cells, which discover individual preferences -;are effective at detecting sour, sweet, bitter and umami stimulation. A research team headed by Kathryn Medler at the University at Buffalo reports this discovery in a research published 13th August in

    Seeing how the malaria can withstand fever’s warmth

    Even when a man suffering from malaria is burning up with fever and too ill to operate, the little blood-eating parasites lurking inside them continue to flourish, relentlessly growing and multiplying as they gobble up the host’s red blood cells. The single-celled Plasmodium parasites that cause 200 million cases of malaria annually can withstand feverish

    Bruker presents Vutara™ VXL tbest-in-class super-resolution magnifying lens and spatial science investigation abilities

    Vutara VXL serves as a biological microscopy workstation for research on DNA, RNA and proteins, from macromolecular complexes and super-structures, to chromatin structure and chromosomal substructures, to studying functional connections in genomes and in various subcellular organelles. This novel system supports innovative spatial biology research in extracellular matrix structures, extracellular vesicles (EV), virology, neuroscience, and

    Blood vessel deformities start in vein cells

    In the condition called cavernoma, lesions appear in a cluster of blood vessels in the brain, spinal cord or retina. Researchers from Uppsala University can now reveal, at molecular level, these changes originate in vein cells. This new understanding of the condition creates possibility of developing better treatments for patients. The study was published in

    Hematoxylin compounds can specifically kill CALR mutant cancer cells

    Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Researchers of the research team of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the

    Hematoxylin compounds can specifically kill CALR freak disease cells

    Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the

    Polygenic threat ratings from multi-populace information should enhance IBD predictions

    Using genetic data from nearly 30,000 individuals, Mount Sinai researchers have assembled hazard scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The research was published in Gastroenterology on December 24. The researchers found that polygenic risk scores,