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Dear Readers, Welcome to the latest issue of The Magazine
Vutara VXL serves as a biological microscopy workstation for research on DNA, RNA and proteins, from macromolecular complexes and super-structures, to chromatin structure and chromosomal substructures, to studying functional connections in genomes and in various subcellular organelles. This novel system supports innovative spatial biology research in extracellular matrix structures, extracellular vesicles (EV), virology, neuroscience, and live-cell imaging. When combined with Bruker’s unique microscope fluidics unit, Vutara VXL enables multiplexed imaging for targeted, sub-micrometer multiomics in genomics, transcriptomics, and proteomics research. The Vutara VXL software already supports leading-edge methods, such as OligoSTORM, Optical Reconstruction of Chromatin Architecture (ORCA), and DNA PAINT labeling methodologies.
I am thrilled about the release of Vutara VXL, as this instrument is fundamental in making SML microscopy more accessible to the scientific community, and to the spatial 3D genomics research community in particular. Witnessing first-hand Bruker’s software and hardware development to enhance the spatial genomics capabilities that are required for my research bears testament to both their dedication and the functionality and versatility of the Vutara platform.”-Jennifer E. Phillips-Cremins, Ph.D., Associate Professor of Biotechnology and Genetics, University of Pennsylvania
We believe that enabling 3D single-molecule localization microscopy in the hands of more researchers will further advance a better understanding of cellular biology at the nano level, particularly in the emerging field of spatial omics imaging. Combined with its large field of view and ability to perform optical nanoscopy, Vutara VXL delivers multimodal capabilities and high-throughput data acquisition to enable a wider range of studies for spatially resolved genomics and transcriptomics.”-Xiaomei Li, Ph.D., Vice President and General Manager, Bruker’s Fluorescence Microscopy Business
Around Vutara VXL Depending on the Vutara super-resolution platform’s proprietary biplane technology, proven industry-leading capabilities with fully integrated fluidics with infinite multiplexing possible, and powerful analytical software, the new Vutara VXL facilitates scientific research from experiment initiation and data collection through analysis to book. The system enables researchers to obtain intrinsic 3D super-resolution data and achieve 20 nm localization precision in XY, 50 nm in Z for natural dyes, as well as finer with DNA PAINT probes.
A proprietary emission route enables the system to achieve low background fluorescence, even in thick samples, routinely imaging large Z volumes in tissue slices up to 30 μm in depth at arbitrary distances from the coverslip. With the SRX software bundle and its Quantitative Localization Microscopy analysis package, Vutara VXL eases the entire imaging process from acquisition and localization, and provides in-depth visual and quantitative information from biological samples in a single, seamless workflow.
Utilizing real-time localization analysis and data visualization, multi-location recording abilities, and scripting functions for automatic data analysis, conclusion of an entire workflow cycle can be accomplished in a couple of minutes, providing a significant enhancement to work throughput. As a multi-modality workstation for single-molecule localization microscopy in addition to conventional diffraction-limited widefield imaging, Vutara VXL is an ideal platform for bioinformatics, such as looking at the spatial distribution of the transcriptome in conjunction with high-resolution genomic or proteomic imaging.
Story source:
Bruker Nano Surfaces
