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Automation of sample preparation has become the most significant advancement to the workflow of contemporary laboratories across pharmaceutical research and development (R&D), clinical diagnostics, biotechnology, and analytical chemistry. Recent advancements in automated sample preparation can improve a laboratory’s workflow with improved accuracy, operational cost efficiency, and timeliness of results.
Preparation of laboratory samples using manual, traditional methods, was inefficient in terms of scalability and reproducibility of samples. Introduction of AI and smart data integration has transformed modern automated sample preparation methods. These methods provide improved reproducibility of samples, compliant data, and increased efficiency of laboratory workflows.
Robotic liquid handlers are perhaps the most ubiquitous automation technology in modern laboratories. These systems can perform the accurate transfer of liquids, serial dilutions, sample normalization, and the preparation of assay plates.
The most advanced liquid handling systems incorporate AI and collaborate in the automation of system calibration, contamination control, and dispenser channels. These innovations significantly reduce variability within the laboratory and improve workflow throughput.
AI-based workflow optimization tools are being integrated into automated sample preparation systems. Through monitoring sample quality, AI systems can suggest optimal sample preparation parameters and anticipate errors that may occur during subsequent steps.
This technology helps reduce sample waste while decreasing instrument downtime.
SPE is still a necessary process in both analytical and pharmaceutical settings. A key advantage of an automated system for SPE is the potential to improve the speed of purification and minimize operator handling. Advanced SPE systems allow for rapid purification and SPE for more complex biological and chemical matrices.
With increased automation, integrative systems in a laboratory setting are becoming more popular. Automation of sample preparation, sample analysis, and sample result communication in a single product decreases time restraints and optimizes operations of laboratory workflows, particularly in clinical settings and molecular biology workflows.
With the use of automation systems that utilize magnetic beads, workflows for purification of proteins and nucleic acids are revolutionized. Magnetic beads offer a fast and efficient way to isolate bio-targets. The magnetic bead system is the choice for molecular biology and diagnostics workflows, including PCR, genomics, and infectious diseases.
Microfluidic preparation systems allow for the quick and easy preparation of samples and a comprehensive analysis for small sample sizes. Due to the use of microfluidic prep systems, laboratories are able to conserve reagents and improve the efficiency of prep time and the sensitivity of the analysis.
Modern automation systems combine barcode reading, RFID technology, and digital tracking systems to ensure complete sample traceability.
This advancement is particularly useful for industries working under stringent regulations, such as pharmaceuticals, healthcare diagnostics, and biobanking.
Laboratories that rely on cloud-connected sample preparation systems can control and assess how their operations function and then share sensitive information with collaborators around the world.
This technology supports the development of smart laboratory systems.
Innovative homogenization systems now disrupt, grind, and mix tissues and other laboratory samples more consistently than ever before.Improvements to sample quality are revolutionizing laboratory science in pharmaceuticals, food testing, environmental studies, and biological research.
Collaborative robots, Cobots, are being introduced into laboratories to operate alongside traditional staff, as they promote safe and easy operations. Compared to conventional robots used in manufacturing, Cobots are smaller and simpler to implement. The use of these robots in laboratories allows personnel to perform advanced scientific evaluations.
