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Dear Readers, Welcome to the latest issue of The Magazine
APC Microbiome Ireland (APC), University College Cork (UCC), published today in the leading international scientific magazine Nature Aging a new approach to reverse aging-related brain deterioration and cognitive function via microbes in their gut.
One of the major global challenges as our population ages is how to preserve healthy brain function. This groundbreaking research has opened up new therapeutic avenues in form of microbial-based interventions that slow down brain aging, and other cognitive problems.
Researchers from the Brain-Gut Microbiota lab at APC were responsible for the work. Prof John F. Cryan is Vice President Research & Innovation at University College Cork. He also serves as Principal Investigator at APC Microbiome Ireland, an SFI Research Centre, based in University College Cork.
The importance of microbes in the gut is being recognized more and more in medicine and physiology. The latest mouse study shows that microbes can be transplanted from young animals into older ones to rejuvenate brain and immune function. Professor John F. Cryan said, “Previous research by the APC as well as other international groups has shown that the microbiome in the gut plays a key part in aging and the aging process. The new research could be a game changer, as it has shown that the microbiome can reverse age-related brain decline. There is also evidence of an improvement in cognitive function and learning ability. While these are very exciting findings, Cryan warns that it is still early days. More work is needed to translate them into humans.
This research of Prof. Cryan and colleagues further demonstrates the importance of the gut microbiome in many aspects of health, and particularly across across the brain/gut axis where brain functioning can be positively influenced. The study opens up possibilities in the future to modulate gut microbiota as a therapeutic target to influence brain health.”Prof Paul Ross, APC Director
Dr Marcus Boehme, co-first authors, led the study along with Thomaz Bastiaansen and Katherine E. Guzzetta as PhD students.
University College Cork (UCC)
Boehme, M., et al. (2021) Microbiota from Young Mice Counteracts Selective Age-Associated Behavioral Deficits. Nature Aging. doi.org/10.1038/s43587-021-00093-9.
