Subscribe to our Newsletters !!
Using antibodies in different laboratory settings,
Imafit is platinum cured grade silicone hose reinf
Also known as “walking pneumonia,” Mycoplasma
TM Media is pleased to add the prestigious Elets 6
Alembic Pharmaceuticals Limited (Alembic) today an
It is important to understand that natural remedie
Dear Readers,Welcome to the latest issue of Microb
There are two thermal analysis techniques that are very important. These are Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). Nonetheless, their differences in information provided and principles on which they are based make them vary.
Principle: In TGA, the change in mass of a sample as it is heated, cooled or held at a constant temperature is measured while focusing mainly on mass changes.
Measurement: The sample is kept in a balance inside the furnace; therefore, any change in its mass caused by changes in temperature can be recorded by the balance. This data can then be plotted as either mass loss/gain versus temperature/time.
Principle: DSC measures heat flow into or out of a sample as it is heated or cooled with emphasis on thermal transitions and heat flow through the material.
Measurement: The sample side by side with a reference one are heated or cooled under closely controlled conditions. It records the difference in heat flow between the two substances being compared. Then this data can be plotted as heat flow against temperature/time.
Also read:Mastering the Art of Interpreting Thermogravimetric Analysis Data
Decomposition Temperatures: Identifies temperatures at which a material decomposes.
Composition: Determines materials’ composition through quantifying loss of mass due to different thermal events such as water loss or decomposition of organic materials.
Stability: Gives information about how thermally stable and volatile materials are.
Thermal Transitions:Identify phase transition such as melting point, crystallization, glass transition.
Heat Capacity:Measure of heat capacity of materials with respect to temperature.
Enthalpy Changes:Quantifies changes in enthalpy due to phase transitions or chemical reactions.
Polymer Analysis: Looking for degradation and compositional analysis.
Pharmaceuticals: Stability studies and formulation.
Materials Science: Thermal stability of materials and composites.
Environmental Science: Ash content and volatile components in samples.
Polymer Science: Characterize melting points, glass transitions, crystallization behavior
Pharmaceuticals: Polymorphism, purity
Food Science: Analyzing thermal properties of food ingredients, formulations
Materials Science: Investigating thermal transitions and phase changes in materials
Sample Size: Usually larger sample sizes are required compared to DSC.
Sample State: Solids; Liquids; Powders
Environment: inert or oxidative or reactive atmosphere depending on the analysis
Sample Size: Requires lesser amounts
Sample State: Mainly solids liquids while others can also handle powders or gels if suitable sample holders are used
Environment : inert ,oxidative controlled atmospheres
Thermogram – this is a plot of mass vs temperature /time showing steps where mass decreases or increases.
Analysis – interpretation of the weight loss/gain as a function of temperatures helps identify degradation steps, composition, thermal stability..
Thermogram – this is a plot of heat flow vs temperature/time indicating endothermic/exothermic transitions. +Analysis – peaks represent thermal events such as melting/crystallization, the area under the curve representing heat involved in these transitions.
A comprehensive understanding of the thermal behavior of a material can be obtained by combining TGA and DSC. For example:
TGA detects weight loss due to decomposition, and DSC can provide information about the temperature and nature of phase transitions that occur during the process of decomposition.
