Researchers utilize human stem cells and bioengineered platform to construct entire working thymus Kumar Jeetendra | December 11, 2020 Their work is an important step towards having the ability to build artificial thymi that could be utilised as transplants. The thymus is an organ in the chest where T lymphocytes, which play a vital role in the immune system, mature. If the thymus doesn’t work properly or doesn’t form during foetal development in the …
Pig stem cells offer another approach to develop human organs for transplantation Kumar Jeetendra | December 18, 2020 In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly generated stem cells from cows, when injected into embryos, contributed to the growth of only the organ of interest (the embryonic …
Study clarifies the impact of getting old on hematopoietic stem cells Kumar Jeetendra | December 25, 2020 By shifting mouse elderly hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was shown that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. On the other hand, the function of elderly HSCs failed to recover in the young bone marrow …
New UCLA-formed gadget moves mitochondria into at least 100,000 or more beneficiary cells Kumar Jeetendra | January 1, 2021 Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput way of transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes and metabolic disorders. A study, published …
Research finds new proof about the systems controlling skin repair and regeneration Kumar Jeetendra | January 19, 2021 As the air continues to dry and temperatures drop, the yearly battle against dry hands and skin has officially begun. New research from Northwestern University has discovered new evidence deep within the skin about the mechanisms controlling skin renewal and repair. Skin’s barrier function gives it the unique ability to fight winter woes and keep …
Scientists find uncommon hereditary disorder that influences the brain, heart and facial highlights Kumar Jeetendra | January 21, 2021 Researchers at the National Institutes of Health have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart and facial features. Named linkage-specific-deubiquitylation-deficiency-induced embryonic defects syndrome (LINKED), it is caused by a mutated version of the OTUD5 gene, which interferes with key molecular actions in embryo development. The findings indicate …
Researchers develop little intestinal cells from human-actuated pluripotent stem cells Kumar Jeetendra | February 8, 2021 A group of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. They assert that the grown cells may be used for laboratory studies focusing on human small intestinal drug metabolism and transport. Because of this, studies on the absorption …
Novel finding could prompt better medicines for Type 1 and Type 2 diabetes Kumar Jeetendra | February 13, 2021 Monash University researchers have discovered the barrier to β-cell (beta mobile ) regeneration which could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage. The human body does not repair itself very well, with our liver the only organ that can regenerate economically. We have limited capacity to …
Researchers concentrate how a single gene alteration may have isolated modern humans from extinct hominins Kumar Jeetendra | February 16, 2021 As a professor of pediatrics and molecular and cellular medicine at University of California San Diego School of Medicine, Alysson R. Muotri, PhD, has long studied how the brain develops and what goes wrong in neurological disorders. For nearly as long, he has also been curious about the evolution of the human brain -; what …
Study discoveries help clarify the variety of cancers in various Li-Fraumeni patients Kumar Jeetendra | February 23, 2021 The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several kinds of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations. Recent studies suggest that some people with inherited p53 …
Researchers describe the systems that manage embryonic stem cells Kumar Jeetendra | March 26, 2021 Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have clarified the mechanisms, unknown to date, included in maintaining embryonic stem cells in the best possible condition for their use in regenerative medicine. The results, published in Nature Communications, helps to find novel stem-cell therapies for …
Study assesses stem cells’ capacity to forestall significant reason for death in preterm newborn Kumar Jeetendra | April 21, 2021 A phase 2 clinical trial whose results were published today in STEM CELLS Translational Medicine might point to a way to conquer bronchopulmonary dysplasia (BPD), a significant cause of death in preterm infants. The study, conducted by researchers at Samsung Medical Center, Sungkyunkwan University and Asan Medical Center Children’s Hospital in Seoul, evaluates the efficacy …
