Intense openness of lung tissue to vape airborne lesserly affects gene expressionthan cigarette smoke Kumar Jeetendra | March 21, 2021 A new peer-reviewed study published in the journal Toxicological Research & Application reveals acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression in contrast to smoke from combustible cigarettes. The study included sub-cytotoxic vulnerability to cells in a 3D human bronchial model (MucilAirTM) to nicotine-containing vape …
Bacteria residing within inside tumor cells can support malignant growth immunotherapy Kumar Jeetendra | March 22, 2021 Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. The study may also help clarify the connection between immunotherapy and the intestine microbiome, describing the findings of earlier research that the microbiome impacts the success of immunotherapy. Immunotherapy remedies of the last decade or so have dramatically improved healing …
Researcher find a gene mutation connected to schizophrenia Kumar Jeetendra | March 24, 2021 Researchers at The Feinstein Institutes for Medical Research, in collaboration with Columbia University, have identified a gene mutation that could result in schizophrenia, a chronic brain disease that affects nearly 1 percent of the planet’s inhabitants. The findings, published in today in Neuron, could lead to novel treatment strategies. The research group, headed by Todd …
Researchers describe the systems that manage embryonic stem cells Kumar Jeetendra | March 26, 2021 Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have clarified the mechanisms, unknown to date, included in maintaining embryonic stem cells in the best possible condition for their use in regenerative medicine. The results, published in Nature Communications, helps to find novel stem-cell therapies for …
Scientists recognize neural circuit associated with reciprocally controlling weight gain and despondency Kumar Jeetendra | March 27, 2021 Research has found that obesity and mental disorders such as depression and anxiety seem to often go together. Researchers at Baylor College of Medicine and cooperating institutions are providing new insights into this association by identifying and characterizing a novel neural circuit that mediates the reciprocal control of feeding and mental conditions in mouse models. …
Study uncovers molecular mechanisms of drug resistance in Mycobacterium tuberculosis Kumar Jeetendra | April 9, 2021 A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way by which Mycobacterium tuberculosis survives in iron-deficient states by using rubredoxin B, a protein by a rubredoxin family that play an essential role in adaptation to changing environmental conditions. The new study is part of …
Scientists use genetics to recognize likely drugs for early administration of COVID-19 Kumar Jeetendra | April 12, 2021 A new study using human genetics indicates researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine at March 2021. The purpose is to identify present drugs, either FDA-approved or in clinical development for other conditions, that can …
Small SARS-CoV-2 protein may have huge ramifications for future COVID-19 medicines Kumar Jeetendra | April 12, 2021 A very small protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future therapies, according to a team of Penn State researchers. Using a novel toolkit of approaches, the scientists uncovered the first full structure of the Nucleocapsid (N) protein and discovered how antibodies from COVID-19 patients interact with …
Imbalanced bacterial community in the gums connected to Alzheimer’s infection biomarker Kumar Jeetendra | April 12, 2021 Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta–a key biomarker for Alzheimer’s disease–in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine. However, this imbalance in oral bacteria was not associated with another Alzheimer’s biomarker …
Genetic variants that sway protein restricting in immune cells can cause autoimmune disease Kumar Jeetendra | April 17, 2021 Certain genetic variants that cause modified protein binding in immune cells, are also seen in people at high risk of some autoimmune diseases, new research has found. Researchers from the Wellcome Sanger Institute, Josep Carreras Leukaemia Research Institute in Spain, and the MRC London Institute of Medical Sciences (LMS) discovered that specific genetic variants, which …
Researchers enlighten how a few antibodies can viably disable ebolaviruses Kumar Jeetendra | April 18, 2021 Some survivors of ebolavirus outbreaks create antibodies that may broadly neutralize those viruses–and today , scientists at Scripps Research have illuminated how these antibodies can disable the viruses so efficiently. The insights might be helpful for developing effective treatments. Ebolavirus is a family of often-deadly viruses that includes Ebola virus and lots of lesser-known viruses …
New examination reveals insight into complex brain measure that learns and structure new memories Kumar Jeetendra | April 19, 2021 Making memories involves over seeing friends or taking photos. How neurons do so –reaching out arm-like dendrites to communicate with other neurons–requires a ballet of genes, signaling molecules, cellular scaffolding and protein-building machinery. A new study from scientists at Scripps Research and the Max Planck Florida Institute for Neuroscience finds a fundamental role for one …
