Trinity crew uncovers mutations connected with early onset dementia Kumar Jeetendra | December 22, 2020 Researchers at Trinity College Dublin today announced a significant advance in our knowledge of an early onset form of dementia which may also advance our understanding of conditions such as Alzheimer’s disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterized by mutations in a gene named Colony stimulating …
New UCLA-formed gadget moves mitochondria into at least 100,000 or more beneficiary cells Kumar Jeetendra | January 1, 2021 Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput way of transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes and metabolic disorders. A study, published …
Corning to feature most current product in 3D cell culture portfolio at SLAS2021 Kumar Jeetendra | January 23, 2021 Corning Incorporated will highlight its hottest technologies that support the advancement of 3D cell culture, automation, and drug discovery in this year’s virtual Society for Laboratory Automation and Screening (SLAS) seminar on Jan. 25 through 27. Now more than ever, tools used to ease scale-up, reproducibility, and consistency of 3D cell culture are helping empower …
Protein alteration adds to degeneration of neuronal populaces in Huntington’s infection Kumar Jeetendra | February 1, 2021 A study in which UB scientists have taken part states that alterations in the levels of one of those proteins, lamin B1, add to the degeneration of distinct brain neuronal populations in Huntington’s disease. Caused by a mutation in the huntingtin gene, this pathology features involuntary movements, cognitive deficit, and psychiatric disorders, and has no …
Sulforaphane draws out life expectancy and healthspan of C. elegans through insulin/IGF-1 flagging Kumar Jeetendra | February 4, 2021 Aging-US released”Sulforaphane boosts C. elegans longevity and healthspan through DAF- 16/DAF-2 insulin/IGF-1 signaling” which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its impact on healthspan and longevity are unclear. The writers used the C. elegans nematode version and fed the wildtype and 9 mutant strains ±sulforaphane. Sulforaphane increased the …
Gene panel test empowers exceptionally exact diagnosis of liposarcomas Kumar Jeetendra | February 5, 2021 Scientists have leveraged the latest advances in RNA technology and machine learning methods to develop a gene panel evaluation which allows for highly accurate diagnosis of the most frequent kinds of liposarcoma. The new assay is described in The Journal of Molecular Diagnosis, published by Elsevier. Liposarcomas are a type of malignant cancer that is …
Compounds in green and black tea relax blood vessels by activating ion channel proteins Kumar Jeetendra | March 9, 2021 A new study from the University of California, Irvine shows that chemicals in both black and green tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Released in Cellular Physiology …
Killing antibodies actuated by COVID-19 vaccines less successful against new variants Kumar Jeetendra | March 15, 2021 SARS-CoV-2, the virus that causes COVID-19, has mutated through the pandemic. New variants of this virus have arisen around the world, including variants that might possess increased capacity to spread or evade the immune system. Such variations have been identified in California, Denmark, the U.K., South Africa and Brazil/Japan. Recognizing how well the COVID-19 vaccines …
CN Bio presents the PhysioMimix™ OOC Multi-Organ Microphysiological System Kumar Jeetendra | March 17, 2021 CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS. The next-generation system unites CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to …
Imbalanced bacterial community in the gums connected to Alzheimer’s infection biomarker Kumar Jeetendra | April 12, 2021 Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta–a key biomarker for Alzheimer’s disease–in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine. However, this imbalance in oral bacteria was not associated with another Alzheimer’s biomarker …
Novel technique gives quicker and more exact diagnostics in histopathology Kumar Jeetendra | May 1, 2021 Histology is the study of biological cells at a microscopic level. Also called microscopic anatomy, histology is widely used to offer identification of cancer and other diseases. For instance, tissue samples obtained during surgery might help to ascertain whether additional surgical action is needed, and additional surgery may be avoided if a diagnosis can be …
Mild cases of COVID-19 give enduring antibody, shows study Kumar Jeetendra | May 24, 2021 Months after recovering from mild cases of COVID-19, people still possess immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells could persist for a lifetime, churning out antibodies all of the while. The …
