Researchers distinguish systems behind inflammasome initiation by fungal pathogens Kumar Jeetendra | December 3, 2020 Researchers at St. Jude Children’s Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, is a leading cause of infection-associated deaths in people with compromised immune systems. The work provides clues to a potential therapeutic approach for treating infectious and …
Colon lining discharges hydrogen peroxide to shield the body from gut microorganisms Kumar Jeetendra | December 10, 2020 Scientists at UC Davis Health have discovered that an enzyme in the colon lining releases hydrogen peroxide (H2O2) – a known disinfecting chemical – to protect the body from gut microbes. Their study, published Dec. 9 in the journal Cell Host and Microbe, sheds light on the way microorganisms are spatially organized in the colon. …
Study distinguishes protein as likely restorative objective for leishmaniasis vaccine Kumar Jeetendra | December 12, 2020 According to the results of research led by the Complutense University of Madrid (UCM), among the various strategies deployed by the Leishmania parasite to avoid tripping the human immune system is to trigger the SHP-1 protein. The parasite does this by secreting a molecule capable of interacting with the Mincle receptor expressed by antigen-presenting dendritic …
Researchers arrive at significant achievement in leishmaniasis immunization advancement Kumar Jeetendra | January 11, 2021 Scientists have taken an important step forward in creating a controlled human infection model to test leishmaniasis vaccines. The University of York-led study identified and characterized a new strain of Leishmania parasite that will form the basis of a new controlled human infection model for the disease which is transmitted by the bite of sand …
Putatively juvenile dendritic cells may actuate hearty resistant reactions in young children Kumar Jeetendra | January 20, 2021 A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers demonstrates that putatively immature dendritic cells found in young children are able to induce strong immune responses. Dendritic cells are a vital component of the innate immune system, which represents the body’s first line of defense against infectious agents and tumor cells. Their job is to trigger …
Corning to feature most current product in 3D cell culture portfolio at SLAS2021 Kumar Jeetendra | January 23, 2021 Corning Incorporated will highlight its hottest technologies that support the advancement of 3D cell culture, automation, and drug discovery in this year’s virtual Society for Laboratory Automation and Screening (SLAS) seminar on Jan. 25 through 27. Now more than ever, tools used to ease scale-up, reproducibility, and consistency of 3D cell culture are helping empower …
Second-generation double antibody shields from SARS-CoV-2 and its tried variations Kumar Jeetendra | January 25, 2021 Additionally, it prevents the virus from mutating to resist the treatment . Antibody-based immunotherapy was already proven to work against COVID-19 but faces two chief obstacles: it requires to work against the circulating viral variants; it has to avoid formation of new variants, that can rapidly ensue using a mechanism similar to that leading to …
New investigation shows interface between intestinal microbiota and maternal behavior Kumar Jeetendra | January 30, 2021 As scientists learn more about the microorganisms that colonize the human anatomy –collectively referred to as the microbiota–one area of extreme interest is the effect that these microbes can have on the mind. A new study headed by Salk Institute scientists has identified a strain of E. coli bacteria that, when living in the guts …
Diphtheria is developing to get antibiotic-resistant safe and could prompt vaccine escape Kumar Jeetendra | March 8, 2021 Diphtheria – a comparatively easily-preventable infection – is evolving to become immune to a range of types of antibiotics and in the future could lead to vaccine escape, warn an international group of researchers in the UK and India. The researchers, led by scientists at the University of Cambridge, say that the impact of COVID-19 …
NIAID sets up a clinical research organization to improve comprehension of child asthma Kumar Jeetendra | April 25, 2021 This nationwide network will conduct observational studies and clinical trials to improve understanding of asthma and develop prevention and treatment approaches tailored to children of low-income families residing in urban communities. NIAID plans to provide approximately $70 million over seven years to support the CAUSE network. This new initiative expands and extends NIAID’s long-standing attempts …
Researchers develop experimental direct-acting antiviral treatment to treat COVID-19 Kumar Jeetendra | May 18, 2021 An international team of scientists from the Menzies Health Institute Queensland (MHIQ) at Griffith University and from City of Hope, a research and treatment center for cancer, diabetes and other life-threatening diseases in the U.S., have developed an experimental direct-acting antiviral therapy to treat COVID-19. Conventional antivirals reduce symptoms and help people recover earlier. Examples …
Specific enzymes shield the human skin and body from microorganisms, viruses Kumar Jeetendra | May 22, 2021 The human body is constantly exposed to various environmental celebrities, from viruses to bacteria to fungi, but the majority of these parasitic organisms provoke little if any response from our skin, which is charged with monitoring and shielding from external dangers. Until now, researchers weren’t quite sure how that happened — and why our skin …
