Hematoxylin compounds can specifically kill CALR mutant cancer cells Kumar Jeetendra | December 11, 2020 Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Researchers of the research team of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the …
IGC analysts get three out of six European Research Council grants Kumar Jeetendra | December 11, 2020 Since the establishment of the European Research Council in 2008, the IGC has secured 17 of the competitive grants (7 Beginning, 8 Consolidator and two Advanced). In 2021, with the beginning of the new grants awarded this month, it will have ten active grants. The year of 2020 marks a total of 327 researchers chosen …
New information shows empowering results for patients with neuro-degenerative blinding eye illness Kumar Jeetendra | December 16, 2020 New data published in the Journal Science Translational Medicine shows encouraging results in a worldwide clinical trial for patients diagnosed with the neuro-degenerative blinding eye disease; Leber Hereditary Optic Neuropathy (LHON. The disease is an inherited type of vision loss estimated to affect 1 in 30,000 to 50,000 individuals. LHON most often afflicts individuals with …
Skin may assist with foreseeing future heart issues Kumar Jeetendra | December 17, 2020 Our skin informs us when we have spent too much time in sunlight or when the dry air of winter has sucked away too much moisture. Now Jefferson researchers find that the skin may also foretell problems unrelated to the protective barrier. An international group of researchers headed by Jouni Uitto, MD, PhD, a Professor …
Another way to deal with distinguish genomic areas in our cerebrum that add to make us human Kumar Jeetendra | December 17, 2020 With just 1% gap, the human and chimpanzee protein-coding genomes are remarkably similar. Knowing the biological characteristics that make us human is a part of a fascinating and intensely debated line of study. The paper is printed in Science Advances. Gene expression, not gene arrangement To describe what sets human besides their ape relatives, researchers …
new cGMP plasmid DNA manufacturing facility construction announced by Thermo Fisher Kumar Jeetendra | December 18, 2020 Thermo Fisher Scientific, the world leader in serving science, today announced the construction of a new cGMP plasmid DNA manufacturing facility in Carlsbad, Calif. The site will expand the company’s clinical and commercial capabilities for cGMP plasmid DNA used as a critical raw material to develop and manufacture cell and gene-based therapies including life-saving cancer …
Study recognizes biomarker gene mark that demonstrates likely liver toxicity Kumar Jeetendra | December 19, 2020 When agrochemical and pharmaceutical companies develop new products, they must test extensively for potential toxicity before obtaining regulatory approval. This testing usually involves lengthy and expensive animal research. A research team at University of Illinois has developed a gene biomarker identification technique that cuts the testing process down to a couple of days while still …
Hematoxylin compounds can specifically kill CALR freak disease cells Kumar Jeetendra | December 20, 2020 Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Scientists of the research group of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the …
New comprehension of physical properties of chromatin may show how genome is encoded and decoded Kumar Jeetendra | December 21, 2020 University of Alberta researchers have found an answer to a basic question in genomic biology that has eluded scientists because the discovery of DNA: Over the nucleus of our cells, is the complex package of DNA and proteins called chromatin a solid or a liquid? Previously, fields like biochemistry operated under the premise that chromatin …
Trinity crew uncovers mutations connected with early onset dementia Kumar Jeetendra | December 22, 2020 Researchers at Trinity College Dublin today announced a significant advance in our knowledge of an early onset form of dementia which may also advance our understanding of conditions such as Alzheimer’s disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterized by mutations in a gene named Colony stimulating …
Researchers find out protein that adjusts gene interest to healthy nutrient stages in roundworms Kumar Jeetendra | December 23, 2020 Changing a fertilized egg into a fully functional adult is a complicated endeavor. Cells must split, move, and mature at specific times. Developmental genes control that process, turning on and off at a choreographed way. However, the environment affects development. They discovered a master switch developing worms use to pause growth when nutrients are scarce. …
Study clarifies the impact of getting old on hematopoietic stem cells Kumar Jeetendra | December 25, 2020 By shifting mouse elderly hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was shown that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. On the other hand, the function of elderly HSCs failed to recover in the young bone marrow …
