New investigation shows interface between intestinal microbiota and maternal behavior Kumar Jeetendra | January 30, 2021 As scientists learn more about the microorganisms that colonize the human anatomy –collectively referred to as the microbiota–one area of extreme interest is the effect that these microbes can have on the mind. A new study headed by Salk Institute scientists has identified a strain of E. coli bacteria that, when living in the guts …
New gold-nanoparticle probes for target recognizable proof of bioactive small molecules Kumar Jeetendra | February 2, 2021 The development of pharmaceutical treatments is difficult — clinicians and researchers know a certain drug can regulate particular functions, but they may not understand how it actually works. Bioactive small molecules are chemical compounds, such as pharmaceuticals, that can be readily delivered to and interact with a human body’s cells. By binding to specific proteins, …
Sulforaphane draws out life expectancy and healthspan of C. elegans through insulin/IGF-1 flagging Kumar Jeetendra | February 4, 2021 Aging-US released”Sulforaphane boosts C. elegans longevity and healthspan through DAF- 16/DAF-2 insulin/IGF-1 signaling” which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its impact on healthspan and longevity are unclear. The writers used the C. elegans nematode version and fed the wildtype and 9 mutant strains ±sulforaphane. Sulforaphane increased the …
Gene panel test empowers exceptionally exact diagnosis of liposarcomas Kumar Jeetendra | February 5, 2021 Scientists have leveraged the latest advances in RNA technology and machine learning methods to develop a gene panel evaluation which allows for highly accurate diagnosis of the most frequent kinds of liposarcoma. The new assay is described in The Journal of Molecular Diagnosis, published by Elsevier. Liposarcomas are a type of malignant cancer that is …
FDA permits advertising of new remedy just device to lessen wheezing and mild sleep apnea Kumar Jeetendra | February 6, 2021 Now, the U.S. Food and Drug Administration approved marketing of a new prescription only device intended to reduce snoring and moderate obstructive sleep apnea. Unlike devices used while patients sleep, this is the first device used while awake that is intended to improve tongue muscle function, which in time helps prevent the tongue from collapsing …
Hereditary components of human gut microbiota are key to wellbeing Kumar Jeetendra | February 6, 2021 Neanderthals’ gut microbiota already contained some beneficial micro-organisms that are also found within our own intestine. An international research group headed by the University of Bologna achieved this result by extracting and analyzing ancient DNA from 50,000-year-old fecal sediments sampled at the archaeological site of El Salt, near Alicante (Spain). Published in Communication Biology, their …
Researchers develop little intestinal cells from human-actuated pluripotent stem cells Kumar Jeetendra | February 8, 2021 A group of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. They assert that the grown cells may be used for laboratory studies focusing on human small intestinal drug metabolism and transport. Because of this, studies on the absorption …
Altered lipids focus on the body’s endocannabinoid framework to control pain and inflammation Kumar Jeetendra | February 10, 2021 When modified using a process known as epoxidation, two naturally occurring lipids are converted to potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways which promote inflammation and pain, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much stronger effects than the molecules from which they are derived, which also modulate …
Study describes cisplatin-prompted hearing loss in pediatric cancer growth patients Kumar Jeetendra | February 14, 2021 Permanent hearing loss is a common side effect of the medicine, but until now, studies have been too little and too varied to accurately characterize this risk. Today in The Lancet Child & Adolescent Health, researchers at Children’s Hospital Los Angeles published results of the biggest analysis of cisplatin-induced hearing loss to date. The analysis …
Immunomodulatory drugs improve the achievement pace of cancer therapy Kumar Jeetendra | February 15, 2021 Immunomodulatory drugs, for example, Contergan derivatives lenalidomide and pomalidomide, have significantly improved the treatment of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action within this class of drugs. At exactly the exact same time, they identified new revolutionary targeted cancer therapies. …
Novel hydrogel gradually delivers RNA nanovaccines to shrivel tumors Kumar Jeetendra | February 18, 2021 Messenger RNA (mRNA) vaccines to stop COVID-19 have made headlines around the world recently, but scientists also have been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Cancer immunotherapy vaccines operate similarly to mRNA vaccines for COVID-19, except they trigger the immune system to attack tumors rather than …
An upgraded interaction to detach and cleanse magnetic nanoparticles Kumar Jeetendra | February 20, 2021 Magnetic nanoparticles biosynthesized by germs might soon play an significant role in biomedicine and biotechnology. Researchers at the University of Bayreuth have developed and optimized a procedure for the purification and isolation of the particles from bacterial cells. In initial tests, magnetosomes showed good biocompatibility when compared with human cell lines. The results presented in …
