Sloan Kettering Institute specialists offer news answer to 100-year-old malignancy secret Kumar Jeetendra | January 23, 2021 The year 2021 marks the 100th anniversary of a basic discovery that is taught in every biochemistry textbook. In 1921, German doctor Otto Warburg observed that cancer cells harvest energy from sugar sugar in a strangely inefficient manner: instead of”burn” it using cancer cells do what yeast do — they ferment it. This oxygen-independent process …
Altered lipids focus on the body’s endocannabinoid framework to control pain and inflammation Kumar Jeetendra | February 10, 2021 When modified using a process known as epoxidation, two naturally occurring lipids are converted to potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways which promote inflammation and pain, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much stronger effects than the molecules from which they are derived, which also modulate …
Scientists concentrate what the methylation of proteins means for various mitochondrial measures Kumar Jeetendra | February 21, 2021 Diseases of the cells’ energy supply can cause a range of serious ailments, but also appear to be connected to aging. More research is required on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet reveals how an important molecule inside the mitochondria affects their function in mice and fruit …
Compounds in green and black tea relax blood vessels by activating ion channel proteins Kumar Jeetendra | March 9, 2021 A new study from the University of California, Irvine shows that chemicals in both black and green tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Released in Cellular Physiology …
Deforestation in the Amazon builds variety of antibiotic-resistant bacteria Kumar Jeetendra | March 12, 2021 In Brazil, a study conducted by researchers affiliated with the University of São Paulo (USP) and collaborators showed that deforestation in the Amazon causes an increase in the diversity of antibiotic-resistant bacteria. An article on the study, published in Soil Biology and Biochemistry, compares the microorganisms that live in the land of indigenous forest with …
Study maps design and system of a membrane enzyme that assumes part in inflammation, cancer Kumar Jeetendra | March 21, 2021 Most drugs operate via the membranes that surround the body’s cells. The analysis, which is printed in the journal Nature Communications, can make a significant contribution to the development of potential drugs. The cells’ equal to organs, the organelles, are enclosed by membranes. Embedded in the cell’s external and internal membranes are proteins that regulate …
Study uncovers molecular mechanisms of drug resistance in Mycobacterium tuberculosis Kumar Jeetendra | April 9, 2021 A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way by which Mycobacterium tuberculosis survives in iron-deficient states by using rubredoxin B, a protein by a rubredoxin family that play an essential role in adaptation to changing environmental conditions. The new study is part of …
New hereditarily encoded sensor recognizes drugs of abuse Kumar Jeetendra | April 29, 2021 A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell. Compounds associated with …
Researchers examine signal necrotic cells that prompt phagocytic cells to overwhelm the dying cell Kumar Jeetendra | May 8, 2021 As people keep their homes clean and clutter in check, a crew of cells within the body is in charge of clearing the waste that the body generates, including cells that are dying. The housekeeping cells remove unwanted material by a process called phagocytosis, which literally means’eating cells’ “Phagocytosis is quite important for the body’s …
Scientists distinguish new compound that may forestall heart arrhythmia risk from basic drugs Kumar Jeetendra | May 16, 2021 Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that causes regeneration, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs might have a more therapeutic benefit at higher doses, …
New COVID-19 testing innovation is a less expensive, quicker choice to tube-based RT-PCR tests Kumar Jeetendra | May 18, 2021 Throughout the COVID-19 pandemic, supply chain shortages of reagents and test kits have restricted the rapid expansion of clinical testing required to contain the virus. Its accuracy was 100 percent predictive in clinical trials, researchers explain in The Journal of Molecular Diagnostics, published by Elsevier. Sensitivity is critical for early detection of COVID-19 infection where …
New medication like compound could adequately hinder a critical step in malaria parasite life cycle Kumar Jeetendra | May 19, 2021 Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a vital step in the malaria parasite life cycle and are working to develop this compound into a potential first of its type malaria treatment. While drugs and mosquito control have reduced levels of …
