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Research suggests that nutritional supplements that target specific mechanisms that are associated with age-associated cellular decay (AACD), have the potential to improve health and well-being for adults.
“Cellular Nutrition and Its Influence on Age-Associated Cellular Decline,” the latest issue of The Gerontological Society of America’s What’s Hot newsletter with accompanying infographic, provides an overview of current research regarding evidence regarding the influence of nutritional components on health and aging.
Declining mitochondrial health is increasingly being recognized as a common mediator of declining function and development of chronic diseases associated with aging. This report describes contributions of mitochondria to cellular functions and homeostasis and reviews emerging evidence regarding how nutritional components can influence these functions.”Nathan K. LeBrasseur, PT, PhD, FGSA, professor and co-chair of research, Department of Physical Medicine and Rehabilitation and co-director of the Paul F. Glenn Center for Biology of Aging Research, Mayo Clinic
Declining mitochondrial health is increasingly being recognized as a common mediator of declining function and development of chronic diseases associated with aging. This report describes contributions of mitochondria to cellular functions and homeostasis and reviews emerging evidence regarding how nutritional components can influence these functions.”
Nathan K. LeBrasseur, PT, PhD, FGSA, professor and co-chair of research, Department of Physical Medicine and Rehabilitation and co-director of the Paul F. Glenn Center for Biology of Aging Research, Mayo Clinic
Nathan K. LeBrasseur is a member of the newsletter’s content development faculty.
The powerhouse of cells, the mitochondria are also known as the powerhouse of cells. They are responsible for the creation of cellular energy. They regulate cell metabolism and apoptosis, as well as signaling by producing reactive oxygen substances (ROS). ROS, which are highly reactive molecules that are derived from oxygen, are crucial for many biochemical reactions. However, if they are present in excess they can cause molecular damage. Mitochondria also possess their own DNA (mtDNA), which encodes 13 proteins. These proteins are part of the respiratory chain, and can become mutations due to oxidative stress.
AACD is characterized by a decline in metabolism and mitochondrial function. There is evidence to suggest that changes in AACD may trigger age-related diseases and conditions.
“Because abnormalities in the function of mitochondria are associated with many diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases, drivers of mitochondrial dysfunction are promising targets for addressing multiple age-related conditions,” said Roger A. Fielding, PhD, FGSA, a member of the newsletter’s content development faculty who is associate director of the Jean Mayer USDA Human Nutrition Research Center on Aging and professor of medicine at the Tufts University School of Medicine.
It has been proven that healthy eating habits and exercising can reduce the risk of developing age-related diseases.
“Calorie restriction appears to improve markers of disease risk in humans, but its acceptability and feasibility particularly over the long term remains a challenge,” said LeBrasseur. “Dietary supplementation with nutritional components that target specific mechanisms associated with AACD may be an alternative or complementary approach to lifestyle interventions targeting AACD.”
The Gerontological Society of America
