Dexamethasone use could reduce immune checkpoint inhibitor viability in glioblastoma patients Kumar Jeetendra | November 25, 2020 Bottom Line: One of patients with glioblastoma getting an immune checkpoint inhibitor, people who obtained the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival. Journal Where the Study was Released: Clinical Cancer Research, a journal of the American Association for Cancer Research Author: David A. Reardon, MD, clinical director of the …
Study famous how ecDNA fragments pressure gene amplification to generate drug resistance in cancer Kumar Jeetendra | December 26, 2020 Researchers headed by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the puzzle of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to create drug resistance in cancer. The study, published on December 23 in the journal Nature, provides new …
The Cancer Microbiome Atlas gives more clear picture of microbiota living in organs Kumar Jeetendra | January 14, 2021 Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in a variety of organs in both healthy and cancerous states, researchers will now have the ability to find new biomarkers of disease and better understand …
Jellagen dispatches JellaGel™, the principal Collagen Type 0 Hydrogel taking available driving Extracellular Matrix Kumar Jeetendra | January 15, 2021 Jellagen® Limited, a biotechnology company manufacturing high-value Collagen Type 0 derived from jellyfish, announce the launch of their JellaGel™ Hydrogel. 3-dimensaional Hydrogels make it possible for cells to grow and interact with all of their surroundings that makes a massive difference. Cells grown in a 3D model have been shown to be more natural, with …
Putatively juvenile dendritic cells may actuate hearty resistant reactions in young children Kumar Jeetendra | January 20, 2021 A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers demonstrates that putatively immature dendritic cells found in young children are able to induce strong immune responses. Dendritic cells are a vital component of the innate immune system, which represents the body’s first line of defense against infectious agents and tumor cells. Their job is to trigger …
New upkeep treatment for AML shows solid advantage for patients Kumar Jeetendra | January 23, 2021 Patients with acute myeloid leukemia (AML), the most common form of leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance therapy, based on a randomized, international phase 3 clinical …
Resonance-guided vaporization may give better approaches for treating tumors Kumar Jeetendra | February 4, 2021 Sending tiny droplets to a tumor and having them vaporized using focused ultrasound: it might be a new way of tracing a tumor or send drugs locally. Researchers of the University of Twente in The Netherlands now demonstrate a new phenomenon triggering droplet vaporization: it occurs at the exact acoustic resonance frequency and causes fast …
Immunomodulatory drugs improve the achievement pace of cancer therapy Kumar Jeetendra | February 15, 2021 Immunomodulatory drugs, for example, Contergan derivatives lenalidomide and pomalidomide, have significantly improved the treatment of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action within this class of drugs. At exactly the exact same time, they identified new revolutionary targeted cancer therapies. …
Novel hydrogel gradually delivers RNA nanovaccines to shrivel tumors Kumar Jeetendra | February 18, 2021 Messenger RNA (mRNA) vaccines to stop COVID-19 have made headlines around the world recently, but scientists also have been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Cancer immunotherapy vaccines operate similarly to mRNA vaccines for COVID-19, except they trigger the immune system to attack tumors rather than …
Study discoveries help clarify the variety of cancers in various Li-Fraumeni patients Kumar Jeetendra | February 23, 2021 The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several kinds of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations. Recent studies suggest that some people with inherited p53 …
CN Bio presents the PhysioMimix™ OOC Multi-Organ Microphysiological System Kumar Jeetendra | March 17, 2021 CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS. The next-generation system unites CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to …
Bacteria residing within inside tumor cells can support malignant growth immunotherapy Kumar Jeetendra | March 22, 2021 Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. The study may also help clarify the connection between immunotherapy and the intestine microbiome, describing the findings of earlier research that the microbiome impacts the success of immunotherapy. Immunotherapy remedies of the last decade or so have dramatically improved healing …
