Inflammation may add to the determination of C. diff disease, shows study Kumar Jeetendra | January 19, 2021 A new study from North Carolina State University indicates that the inflammation brought on by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and supplying nutrients that enable C. diff to thrive. C. diff is a bacterium that causes diarrhea, often with severe …
Sloan Kettering Institute specialists offer news answer to 100-year-old malignancy secret Kumar Jeetendra | January 23, 2021 The year 2021 marks the 100th anniversary of a basic discovery that is taught in every biochemistry textbook. In 1921, German doctor Otto Warburg observed that cancer cells harvest energy from sugar sugar in a strangely inefficient manner: instead of”burn” it using cancer cells do what yeast do — they ferment it. This oxygen-independent process …
Study shows why children of obese moms have inclination to create metabolic illnesses Kumar Jeetendra | January 27, 2021 A Brazilian study published in the journal Molecular Human Reproduction helps understand why overweight mothers often have children with a propensity to develop metabolic disease during their lifetime, according to previous research. According to the authors,”transgenerational transmission of metabolic disorders” may be associated with Mfn2 deficiency in the mother’s oocytes (immature eggs). Mfn2 refers to …
Childhood diet can modify the gut microbiome for life Kumar Jeetendra | February 3, 2021 Eating too much fat and sugar for a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests. The study by UC Riverside researchers is among the first to demonstrate a significant decrease in the total number and diversity of gut bacteria in mature …
Hereditary components of human gut microbiota are key to wellbeing Kumar Jeetendra | February 6, 2021 Neanderthals’ gut microbiota already contained some beneficial micro-organisms that are also found within our own intestine. An international research group headed by the University of Bologna achieved this result by extracting and analyzing ancient DNA from 50,000-year-old fecal sediments sampled at the archaeological site of El Salt, near Alicante (Spain). Published in Communication Biology, their …
Researchers develop little intestinal cells from human-actuated pluripotent stem cells Kumar Jeetendra | February 8, 2021 A group of scientists from Japan have found success in growing small intestinal cells, akin to those found in the human body, from human-induced pluripotent stem cells. They assert that the grown cells may be used for laboratory studies focusing on human small intestinal drug metabolism and transport. Because of this, studies on the absorption …
Altered lipids focus on the body’s endocannabinoid framework to control pain and inflammation Kumar Jeetendra | February 10, 2021 When modified using a process known as epoxidation, two naturally occurring lipids are converted to potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways which promote inflammation and pain, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much stronger effects than the molecules from which they are derived, which also modulate …
Scientists concentrate what the methylation of proteins means for various mitochondrial measures Kumar Jeetendra | February 21, 2021 Diseases of the cells’ energy supply can cause a range of serious ailments, but also appear to be connected to aging. More research is required on mitochondrial function to find future treatments. A new study involving researchers at Karolinska Institutet reveals how an important molecule inside the mitochondria affects their function in mice and fruit …
A little sensor can be utilized for fast recognition of RNA and DNA Kumar Jeetendra | March 6, 2021 In less than a second, a small sensor used in brain chemistry research can detect the key molecules that provide the genetic instructions for life, RNA, and DNA, a new study from American University shows. The AU researchers believe a sensor is a helpful tool for scientists engaged in clinical research to quantify DNA metabolism, …
Study offers understanding into metabolic pathways hijacked by SARS-CoV-2 for viral replication Kumar Jeetendra | March 16, 2021 When SARS-CoV-2, the virus which causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell’s existing metabolic machinery. The infected cells churn out thousands of viral genomes and proteins while halting the creation of their own sources. Researchers from Brigham and Women’s Hospital, Massachusetts General Hospital (MGH), and the Broad …
CN Bio presents the PhysioMimix™ OOC Multi-Organ Microphysiological System Kumar Jeetendra | March 17, 2021 CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS. The next-generation system unites CN Bio’s in vitro 3D liver model, whose phenotype and functions mimic that in vivo, with a range of other organs to …
Study uncovers molecular mechanisms of drug resistance in Mycobacterium tuberculosis Kumar Jeetendra | April 9, 2021 A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way by which Mycobacterium tuberculosis survives in iron-deficient states by using rubredoxin B, a protein by a rubredoxin family that play an essential role in adaptation to changing environmental conditions. The new study is part of …
