Study shows the effect of ‘reverse antibiotic’ on gram-negative bacteria Kumar Jeetendra | March 5, 2021 Researchers from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy. All bacterial cells contain topoisomerases, a significant group of enzymes that help deal with spatial problems stemming from bacterial cell division related to circular DNA …
Study uncovers molecular mechanisms of drug resistance in Mycobacterium tuberculosis Kumar Jeetendra | April 9, 2021 A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way by which Mycobacterium tuberculosis survives in iron-deficient states by using rubredoxin B, a protein by a rubredoxin family that play an essential role in adaptation to changing environmental conditions. The new study is part of …
Scientists use genetics to recognize likely drugs for early administration of COVID-19 Kumar Jeetendra | April 12, 2021 A new study using human genetics indicates researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine at March 2021. The purpose is to identify present drugs, either FDA-approved or in clinical development for other conditions, that can …
Drug-discovery collaboration discovers potential new antimalarial drug candidates Kumar Jeetendra | April 23, 2021 Potential new antimalarial drug candidates are being developed through an protracted drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation. A collaborative research team discovered compounds with antimalarial activity within a collection of 80,000 drug-like molecules at the Janssen Jump-stARter Compound Library, a …
New hereditarily encoded sensor recognizes drugs of abuse Kumar Jeetendra | April 29, 2021 A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell. Compounds associated with …
Scientists distinguish new compound that may forestall heart arrhythmia risk from basic drugs Kumar Jeetendra | May 16, 2021 Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that causes regeneration, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome. While safe in their current dosages, some of these drugs might have a more therapeutic benefit at higher doses, …
Novel antibody candidate shows powerful binding to different SARS-CoV-2 variant mutations Kumar Jeetendra | September 25, 2021 Twist Bioscience Corporation today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19. The Coronavirus Immunotherapy Consortium (CoVIC) is an academic-industry-non-profit …
The Impact of Genomics on Drug Discovery: Advancements and Challenges Kumar Jeetendra | September 21, 2023 The entire collection of DNA in an organism is known as its genome. The human genome is made up of over 3 billion DNA base pairs, or letters, and is present in almost every single cell of the body. The study of genomes’ structure, function, evolution, mapping, and editing is the focus of the interdisciplinary …
Dealing with Drug Discovery Challenges Kumar Jeetendra | July 31, 2024 Drug discovery is an ever-evolving field of research, branching out into numerous novel routes such as immunotherapies and gene therapy. At this forefront of development, scientists face a host of drug discovery challenges that hinder progress. It is vital that the industry takes steps to reduce costs and increase discovery efficacy for more financially and …
Optimizing Formulations Data Improves Drug Development Kumar Jeetendra | October 2, 2024 hen it comes to drug development, optimizing formulations data is a critical step to streamlining the development process, leading to better therapeutic outcomes, reduced costs, and shorter time to market. The benefits of formulation optimization Formulation data is the intricate information concerning the composition and processes of producing a drug including active pharmaceutical ingredients (API), …
From Lab to Life: How Innovation and Quality Control are Shaping the Pharma Industry Kumar Jeetendra | November 14, 2024 Driven by the need to find better therapies and save lives, the pharmaceutical industry has been motivated to invest in scientific advancement. This motivation has however not made it easy for them to bring drug creation to the market as there are a few stages involved. Aside from research, considerable quality management activities are a …
How Atomic Editing Simplifies Drug Discovery Kumar Jeetendra | May 8, 2025 An emerging technology is sweeping under the radars of numerous scientists, but it advances drug development and discovery at an unprecedented pace. This particular form of development, referred to as atomic editing, simplifies and enhances the methods used by researchers at the molecular and atomic level. What is Atomic Editing?” and “The Impact on Drug …
