Test mRNA-based COVID-19 immunization evokes defensive safe reactions in animals Kumar Jeetendra | July 25, 2020 Two injections of this vaccine were enough to induce robust immunity, completely preventing SARS-CoV-2 infection in mice. MRNA-based vaccines are all attractive options for protecting against SARS-CoV-2 because they may be quickly designed and manufactured at a huge scale within weeks. Moreover, preclinical studies have shown that mRNA-based vaccines cause potent and broadly protective immune …
CRISPR-based framework smothers qualities identified with AAV antibody production Kumar Jeetendra | September 9, 2020 Gene therapy generally is based on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the event of CRISPR-based gene therapies, molecular scissors can then snip out a faulty gene, add in a missing arrangement or enact a temporary change in its expression, but the body’s immune response to AAV can …
Researchers utilize human stem cells and bioengineered platform to construct entire working thymus Kumar Jeetendra | December 11, 2020 Their work is an important step towards having the ability to build artificial thymi that could be utilised as transplants. The thymus is an organ in the chest where T lymphocytes, which play a vital role in the immune system, mature. If the thymus doesn’t work properly or doesn’t form during foetal development in the …
IGC analysts get three out of six European Research Council grants Kumar Jeetendra | December 11, 2020 Since the establishment of the European Research Council in 2008, the IGC has secured 17 of the competitive grants (7 Beginning, 8 Consolidator and two Advanced). In 2021, with the beginning of the new grants awarded this month, it will have ten active grants. The year of 2020 marks a total of 327 researchers chosen …
Pig stem cells offer another approach to develop human organs for transplantation Kumar Jeetendra | December 18, 2020 In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly generated stem cells from cows, when injected into embryos, contributed to the growth of only the organ of interest (the embryonic …
New drug mixture improves blood glucose manipulate and weight reduction in mice Kumar Jeetendra | December 23, 2020 Scientists have demonstrated that adding an experimental cancer drug to a widely used diabetes treatment improves blood glucose control and weight loss in mice, according to a study published today in eLife. The results pave the way for clinical trials of this new drug combination as a more successful long-term remedy for countless individuals with …
Biomarkers can foresee how hereditarily identical cells act distinctively under pressure Kumar Jeetendra | January 10, 2021 A set of biomarkers not traditionally associated with cell fate can accurately forecast how genetically identical cells behave differently under pressure, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually result in more predictable responses to pharmaceutical remedies. Groups of the same types of …
Corning to feature most current product in 3D cell culture portfolio at SLAS2021 Kumar Jeetendra | January 23, 2021 Corning Incorporated will highlight its hottest technologies that support the advancement of 3D cell culture, automation, and drug discovery in this year’s virtual Society for Laboratory Automation and Screening (SLAS) seminar on Jan. 25 through 27. Now more than ever, tools used to ease scale-up, reproducibility, and consistency of 3D cell culture are helping empower …
Second-generation double antibody shields from SARS-CoV-2 and its tried variations Kumar Jeetendra | January 25, 2021 Additionally, it prevents the virus from mutating to resist the treatment . Antibody-based immunotherapy was already proven to work against COVID-19 but faces two chief obstacles: it requires to work against the circulating viral variants; it has to avoid formation of new variants, that can rapidly ensue using a mechanism similar to that leading to …
Researchers concentrate how a single gene alteration may have isolated modern humans from extinct hominins Kumar Jeetendra | February 16, 2021 As a professor of pediatrics and molecular and cellular medicine at University of California San Diego School of Medicine, Alysson R. Muotri, PhD, has long studied how the brain develops and what goes wrong in neurological disorders. For nearly as long, he has also been curious about the evolution of the human brain -; what …
Bacteria residing within inside tumor cells can support malignant growth immunotherapy Kumar Jeetendra | March 22, 2021 Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. The study may also help clarify the connection between immunotherapy and the intestine microbiome, describing the findings of earlier research that the microbiome impacts the success of immunotherapy. Immunotherapy remedies of the last decade or so have dramatically improved healing …
Basic dietary enhancement enhances schizophrenic traits in mice Kumar Jeetendra | April 20, 2021 After additional experiments, including visualizing the fluorescently stained dancing advantage of brain cells, researchers concluded that the nutritional supplement likely protects proteins which build neurons’ mobile skeletons. The supplement betaine was initially isolated from sugar beets and is often associated with sweetness or umami flavor. Healthy levels of betaine come from both outside food sources …