Sample Preparation for Analytical Quality Control – Solutions for Optimized Workflows and Accurate Results

Sample Preparation for Analytical Quality Control – Solutions for Optimized Workflows and Accurate Results


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  • Source: Sartorius

  • Date: 04 Jan,2022

A sample preparation is required before any analysis of complex samples. The sample preparation can be as simple as filtration or dilution, or it may require multiple steps. The selection of the right sample preparation method is crucial for reliable downstream measurements. Conventional methods require significant user intervention, can be time-consuming, and use large amounts of solvent and/or consumables. Quality control (QC), is an essential step in the pharmaceutical and biopharmaceutical industries. Each manufacturer must show that their drugs are consistent produced, safe, effective, and pure.

To meet the ever-increasing QC demands of global regulatory agencies, there are more tests that must be performed by QC laboratories. The quality of the sample preparation is key to your HPLC results. Analytical quality controls play an important role in ensuring the quality of laboratory tests. By being exposed to the same conditions as the samples, analytical quality control material is inserted into the testing process. Analytical Quality Control refers to all processes and procedures that are used to ensure consistent, comparable, accurate, and within specific limits, laboratory analysis results. Quality control starts with sample collection, and ends with data reporting. Laboratory control of analytic performance is a key component to quality control.

Sample preparation

In analytical science, sample preparation refers to the ways in which a sample is treated prior to its analyses. Here I am sharing how to optimize your sample preparation for accurate results.

Optimize Your Sample Preparation for Accurate and Reliable Results

HPLC Sample Preparation

HPLC is one the most popular high-precision analytical techniques. Its primary goal is to produce reproducible and precise results. To be able to inject directly onto an HPLC column, a sample must be prepared properly. To accomplish this, your sample not only needs to be dissolved in the appropriate solvent.

Even more important, it must also be free of particles to rule out interference in the best possible way during detection and to prevent blockage of your column. This labor-intensive sample prep is often a tedious chore that is time-consuming.

Quality Control (QC) Is a Critical Step in the Pharmaceutical and Biopharmaceutical Industry

Every pharmaceutical manufacturer must demonstrate that their products are consistently manufactured, safe, potent, and pure. The number of tests that must be run by QC labs continues to rise to meet the ever-increasing QC requirements of global regulatory agencies.

Our analytical sample preparation solutions combine our legendary quality and reliability with our design wisdom to provide the very best in high-pressure liquid chromatography (HPLC), liquid chromatography–mass spectrometry, ion chromatography (LC-MS, IC), or inductively coupled plasma mass spectrometry (ICP-MS) filtration solutions.

1.Fast, simple, & economical

2.Low retention volumes & maximal recoveries

3.Almost zero leachables or extractables

Lab Weighing

Sartorius offer a wide range of world-renowned laboratory balances that can be tailored to your specific needs. These include ultra-micro and analytical balances as well as mass comparators for calibration. The Sartorius laboratory balances can be used in manufacturing, quality control and pharmaceutical areas, as well academic research and other professional uses. They are designed to meet the highest standards for speed, reliability, and safety. We have designed our balances to give the best results in weighing. We also focus on integrating them into laboratory workflows to improve efficiency, reliability, and ergonomics.


With sample capacities from 0.1 mL up to 5 L, the Sartorius Lab Ultrafiltration range offers something for everyone. Find the ultimate device for your concentration or diafiltration applications in the most comprehensive lab ultrafiltration portfolio.

We cater for most target molecule types with our unique choice of membrane materials, molecular weight cut-offs (MWCOs) and operating modes, including centrifugal, solvent absorption, pressure and crossflow devices.


Sample purification is critical to the success of your experiment. Science isn’t about purifying a protein or a virus or a nanoparticle; it’s about answering a fundamental biological question. Our tools help you decrease your sample purification time through the use of tailored spin columns that offer faster purification with simpler workflows.


The Sartorius Lab Filtration portfolio, from simple filter papers or microporous membranes to the latest innovation in filtration devices, ultrafiltration units, or protein or DNA purification devices, features our commitment to use the best in science and engineering design to provide a product range that not only satisfies most every need, but does so with the ease, performance, quality and consistency that scientists demand today.

A profile of Sartorius

The Sartorius Group is a leading international partner of life science research and the biopharmaceutical industry. With innovative laboratory instruments and consumables, the Group’s Lab Products & Services Division concentrates on serving the needs of laboratories performing research and quality control at pharma and biopharma companies and those of academic research institutes. The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently. The Group has been annually growing by double digits on average and has been regularly expanding its portfolio by acquisitions complementary technologies. In fiscal 2020, the company earned sales revenue of some 2.34 billion euros. At the end of 2020, nearly 11,000 people were employed at the Group’s approximately 60 manufacturing and sales sites, serving customers around the globe.

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