Coronavirus: HIV medications can be utilized in extreme cases, says ICMR

Coronavirus: HIV medications can be utilized in extreme cases, says ICMR

Overview

  • Post By : Kumar Jeetendra

  • Source: Microbioz India

  • Date: 15 Mar,2020

As per ICMR specialists, the consideration of the counter HIV drugs for treating Covid-19 depended on prior proof about their adequacy against SARS and MERS coronaviruses that prompted episodes in various pieces of the world in 2002-03 and 2012, individually, just as the docking examines led by National Institute of Virology, Pune.

Anti-HIV medications, Lopinavir and Ritonavir, can be utilized to treat Covid-19 patients in extreme cases.

India’s top wellbeing research body, the Indian Council of Medical Research (ICMR), has recommended this in the treatment convention for Covid-19 distributed by it in IJMR, a clinical diary.

Lopinavir and Ritonavir, the convention recommends, can be utilized in grown-ups more than 18 years old who are affirmed positive for Covid-19 and have intricacies, for example, extreme respiratory pain, low circulatory strain and new-beginning organ brokenness. It has fixed parameters to choose how extreme the respiratory pain ought to be for the fixed portion mix to be utilized on a patient.

Comparable parameters have been fixed for other potential confusions also, whereupon the medication can be utilized to spare the patients.

As per ICMR specialists, the consideration of the counter HIV drugs for treating Covid-19 depended on prior proof about their viability against SARS and MERS coronaviruses that prompted flare-ups in various pieces of the world in 2002-03 and 2012, separately, just as the docking examines led by National Institute of Virology, Pune.
“Use of IFN-B1b (a drug used for treating multiple sclerosis) and Ribavarin (an antiviral medication used to treat certain respiratory infections, hepatitis C and some viral haemorrhagic fevers) was not considered due to their reported toxicity whereas Oseltamivir (used to treat swine flu) was not considered due to its unproven efficacy against CoVs (coronaviruses),” states the treatment protocol published in Indian Journal of Medical Research (IJMR). The fixed dose drug combination (Lopinavir/Ritonavir 200 mg/50 mg) is to be given two tablets every 12 hours for 14 days or for seven days after becoming symptomatic, whichever is earlier, as per the protocol.

The anti-HIV drugs have been tried on some Covid-19 patients in India already, including the Italian national admitted at Sawai Man Singh hospital in Jaipur, with promising results, said sources.
Recently, in a draft report made public by World Health Organisation, the experts claimed Lopinavir and Ritonavir — either alone or in combination with IFNbeta was the suitable second option for rapid implementation in clinical trials among the repurposed drugs under consideration for Covid-19.

WHO experts claimed that Remdesivir, a drug developed for use against Ebola, is most promising for treating Covid-19.

“This is because the in-vitro (tests performed in test tube) and in-vivo (tests performed in living organism) data for the drug are available for coronaviruses.”

“Further, studies in mice using Remdesivir showed superior efficacy over Kaletra+IFNbeta,” they stated in the draft report. Remdesivir slows the infection of healthy cells by blocking viral replication.

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