Compounds Derived From Marine Micro Organism Play An Important Role Against Drug Resistant Bacteria In Clinical Infections

Overview

• Post By : Kumar Jeetendra


• Source: University of Michigan


• Date: 17 Feb,2015

Researcher from University of Michigan recently published a research study which opens mysterious thoughts over Marine microbes. Researcher suggests an antibiofilm compound derived from marine microbes shows an effective role against drug resistant bacteria in hospital related infections. The important findings published in Feb. 16 in Nature Communications.

According to researcher,

"This is why preventing biofilm formation is such an important research target," said Ashootosh Tripathi, a research fellow in the lab of LSI faculty member David Sherman. Tripathi was co-first author of the study, along with Sung Ryeol Park, a former postdoctoral research fellow in the Sherman lab.

According to study, While experimenting in cell cultures a compounds known as cathuitamycins preventingAcinetobacter baumannii for making bio film this biofilm makes complex around surface which is more resistant to drugs in comparison with other bacteria.

"As antibiotic resistance becomes an increasingly important global health concern, marine microorganisms have a great — and largely untapped — potential to provide new classes of antibiotics and anti-biofilm compounds."

Story Source: University of Michigan

Note: The above story is for information purposes only for more information go through story source.

Journal References

Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi, David H. Sherman. Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nature Communications, 2016; 7: 10710 DOI: 10.1038/ncomms10710