Animal With High Cancer Resistance May Give Hope For Better Cancer Treatment In The Near Future: Research Study

Overview

• Post By : Kumar Jeetendra


• Source: Hokkaido University


• Date: 17 Jun,2016

Researcher from Hokkaido University, Japan found a Naked African Mole Rats with longest living (Up to 30 years) rodents has high cancer resistance property and the stem cells isolated from these mammals are anti tumerogenic.

The team of researcher isolated fibroblast of naked mole rates and converted into pluripotent stem cells and these types of programs pluripotent cells termed as induced pluripotent cells (iPSCs) and these stem cells are able to form tumors when inserted back into animals.

Scientists found negative results when inserted these iPSCs into mice with weak immune system shows they did not form any tumors in compares with human and mouse iPSCs results also depicts that the type of tumor suppressor gene named alternative reading frame (ARF) is suppressed in mice and human while remain active in naked mole rats.

"Further research into the detailed mechanisms underlying ASIS in naked mole-rats may shed new light on cancer resistance in the mole-rats and contribute to the generation of non-tumerogenic human-iPSCs, enabling safer cell-based therapeutics," said Kyoko Miura, an assistant professor at Hokkaido University.

Story Source: Hokkaido University

Journal References:

Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-ichiro Seino, Hideyuki Saya, Hideyuki Okano, Kyoko Miura. Tumor resistance in induced pluripotent stem cells derived from naked mole-rats. Nature Communications, 2016; 7: 11471 DOI: 10.1038/ncomms11471