Polygenic threat ratings from multi-populace information should enhance IBD predictions Kumar Jeetendra | December 25, 2020 Using genetic data from nearly 30,000 individuals, Mount Sinai researchers have assembled hazard scores from a combination of datasets representing distinct ancestral populations that improve prediction of risk for inflammatory bowel diseases (IBD) including Crohn’s disease and ulcerative colitis. The research was published in Gastroenterology on December 24. The researchers found that polygenic risk scores, …
Study famous how ecDNA fragments pressure gene amplification to generate drug resistance in cancer Kumar Jeetendra | December 26, 2020 Researchers headed by Ludwig San Diego Member Don Cleveland and Peter Campbell of the Sanger Center have solved the puzzle of how free-floating circular DNA fragments, which are almost exclusively found in cancer cells, drive gene amplification to create drug resistance in cancer. The study, published on December 23 in the journal Nature, provides new …
Researchers find out how shattered chromosomes make most cancers cells greater aggressive Kumar Jeetendra | December 27, 2020 Cancer is one of the world’s biggest health afflictions because, unlike some diseases, it’s a moving target, constantly evolving to evade and resist treatment. In a paper published in the December 23, 2020 online dilemma of Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the …
Surgery may expand length of endurance for metastatic breast malignant growth patients Kumar Jeetendra | December 28, 2020 They studied nearly 13,000 stage four breast cancer patients and found that those who had surgery as well as their other remedies had a survival advantage over those who had other therapies alone. Stage four breast cancer accounts for 6% of newly-diagnosed breast cancer cases. Systemic treatment, which may include treatments like chemotherapy, hormone therapies …
Scientists grow new framework for direct location of SARS-CoV-2 in aerosols Kumar Jeetendra | December 28, 2020 Researchers in the Polytechnic University of Valencia (UPV), in collaboration with specialists from the University of Valencia (UV), have produced a new system based on a high-sensitivity mass biosensor that continuously monitors signals for the immediate detection of SARS-CoV-2 in environmental aerosols. The device, in prototype stage, makes it possible to appraise the quality of …
Poisonous pesticide transformed into treatment against antibiotic-resistant bacteria Kumar Jeetendra | December 30, 2020 They are used as pesticides and fungicides. However, these substances could be poisonous to humans and cause mutations. As they aren’t frequently used, there’s little data about them in the medicinal chemistry literature. However, it has been suggested recently that the groups of substances that are traditionally avoided can help to fight pathogenic bacteria. Yet, …
Older adults, minorities and individuals with lower salaries face disparities in telemedicine use Kumar Jeetendra | December 31, 2020 After”COVID-19,” the word which most people will remember best from 2020 is very likely to be”social distancing.” While it most commonly applied to social gatherings with family and friends, it has changed how many receive medical attention. However, the COVID-19 pandemic, particularly in the spring of 2020, required increased use of virtual or telephone call …
Sustainable immune dysregulation because of COVID-19 in non-hospitalized patients Kumar Jeetendra | December 31, 2020 COVID-19, which has killed 1.7 million people globally, doesn’t follow a uniform path. Others, especially those with comorbidities, can create severe clinical disease with atypical pneumonia and multiple system organ failure. Since the first cases were reported in December 2019, the SARS-CoV-2 virus that causes COVID-19 has surged into a pandemic, with cases and deaths …
New UCLA-formed gadget moves mitochondria into at least 100,000 or more beneficiary cells Kumar Jeetendra | January 1, 2021 Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a simple, high-throughput way of transferring isolated mitochondria and their associated mitochondrial DNA into mammalian cells. This approach enables researchers to tailor a key genetic component of cells, to study and potentially treat debilitating diseases such as cancer, diabetes and metabolic disorders. A study, published …
Biomarkers can foresee how hereditarily identical cells act distinctively under pressure Kumar Jeetendra | January 10, 2021 A set of biomarkers not traditionally associated with cell fate can accurately forecast how genetically identical cells behave differently under pressure, according to a UT Southwestern study. The findings, published by Cell Reports as a Dec. 1 cover story, could eventually result in more predictable responses to pharmaceutical remedies. Groups of the same types of …
Researchers arrive at significant achievement in leishmaniasis immunization advancement Kumar Jeetendra | January 11, 2021 Scientists have taken an important step forward in creating a controlled human infection model to test leishmaniasis vaccines. The University of York-led study identified and characterized a new strain of Leishmania parasite that will form the basis of a new controlled human infection model for the disease which is transmitted by the bite of sand …
Boosting a characteristic cell cycle could bring down ventilator-related lung damage Kumar Jeetendra | January 12, 2021 An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is very likely to cause further lung damage. In a new study, scientists identified a molecule that’s produced by immune cells during mechanical ventilation to try to decrease …
