Human Microbiome: Role In Organ Or Skin Transplantation

Overview

• Post By : Kumar Jeetendra


• Source: University of Chicago Medical Center


• Date: 23 Jun,2016

We all know that our skin microflora play an important role in many body resistance and first line of defense as well as microbiota of inside play an important role in better digestive control and some research also proved that microbiota of our digestive track is connected to neural information and play an important role in stress management too.

Now the researcher from the University of Chicago Medical Center justifies that Microbiota of our skin include number Viruses, Bacteria play key role in transplantation of skin or other body organ through acceptance or rejection of concern skin or body organ. The concern article recently appears in The Journal of Clinical Investigation.

Under research investigation researcher found that if sterile mice dosed with microbes from conventional, untreated mice, they rejected the skin graft quickly while they retained the skin when treated antibiotic treatment of conventional mice dosed with microbes.

According to researcher,

"The species that form the community of microbes colonizing the mice — and supposedly humans too — have different effects," said Maria-Luisa Alegre, MD, PhD, professor of medicine at the University of Chicago and co-senior author of the study. "One community of bacteria from the normal mice is capable of inducing accelerated rejection of a transplant, but another community of bacteria, those that are left over antibiotics, doesn't have that capacity."

Story source: University of Chicago Medical Center

Journal References:

Yuk Man Lei, Luqiu Chen, Ying Wang, Andrew T. Stefka, Luciana L. Molinero, Betty Theriault, Keston Aquino-Michaels, Ayelet S. Sivan, Cathryn R. Nagler, Thomas F. Gajewski, Anita S. Chong, Caroline Bartman, Maria-Luisa Alegre. The composition of the microbiota modulates allograft rejection. Journal of Clinical Investigation, 2016; DOI: 10.1172/JCI85295