Overview

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• Source: METTLER TOLEDO


• Date: 11 Jul,2025

METTLER TOLEDO Thornton’s 7000RMS™ is a cutting-edge on-line analyzer designed for the real-time measurement of microbial contamination, or bioburden, in pharmaceutical water systems such as Purified Water (PW) and Water for Injection (WFI). This advanced instrument leverages laser-based technology to provide immediate detection and quantification of microorganisms directly from water samples, overcoming the limitations of traditional culture-based methods that are time-consuming and often prone to error.

Revolutionizing Water Purity Monitoring: Real-Time Bioburden Detection with METTLER TOLEDO’s 7000RMS™

Key Advantages of the 7000RMS

1. Immediate Results: Traditional plate count methods require 5 to 7 days to yield results, while the 7000RMS delivers microbial presence detection within seconds, enabling rapid response to contamination events.
2. Enhanced Production Efficiency: Real-time monitoring and trending data allow operators to react promptly, preventing process upsets and ensuring continuous production without delays.
3. Improved Product Quality Control: The technology can detect microorganisms as small as 0.3 μm, including viable but nonculturable (VBNC) bacteria, which traditional methods might miss.

How It Works

The 7000RMS employs a unique combination of two optical measurement techniques:

1. Laser Induced Fluorescence (LIF): Detects fluorescent metabolites like NADH and riboflavin produced by microorganisms, which fluoresce under specific light wavelengths.
2. Mie Scattering: Measures light scattered by particles to help identify microorganisms.

By integrating these established techniques, the analyzer provides a continuous, real-time profile of microbial contamination in high-purity pharmaceutical waters. This immediate insight enables operators to divert contaminated water quickly, minimizing risk to the broader water system and downstream processes.

Impact on Pharmaceutical Water System Management

Using the 7000RMS alongside traditional plate counting can significantly improve pharmaceutical water system operations by reducing the risk of contamination, cutting costs associated with delays, and enhancing regulatory compliance through transparent, continuous microbial monitoring. It represents a transformational step forward in ensuring water quality and product safety in pharmaceutical manufacturing environments.

About METTLER TOLEDO

METTLER TOLEDO is a leading global manufacturer of precision instruments. The Company is the world’s largest manufacturer and marketer of weighing instruments for use in laboratory, industrial and food retailing applications. The Company also holds top-three market positions for several related analytical instruments and is a leading provider of automated chemistry systems used in drug and chemical compound discovery and development.

In addition, the Company is the world’s largest manufacturer and marketer of metal detection systems used in production and packaging. Additional information about METTLER TOLEDO is available at www.mt.com.

Visit us: https://www.mt.com/us/en/home/products/Process-Analytics/Total-Organic-Carbon-TOC-analyzer/thornton-bioburden-analyzer.html

Email us at – [email protected]

Call us toll-free at – 1800 22 8884 & 1800 1028 460