Myeloid cells can smother insusceptible reaction, advance cerebrum metastasis Kumar Jeetendra | October 28, 2020 Scientists have long thought that the brain protects itself from an aggressive immune response to keep inflammation down. However, that evolutionary management may work against it when a cancer cell tries to spread to the brain, researchers at the University of Notre Dame have found. In recently published research in the journal Cell, researchers showed …
Microorganisms in the lungs could impact lung cancer progression and prognosis Kumar Jeetendra | November 11, 2020 Bottom Line: Enrichment of the lungs with oral commensal microbes has been correlated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer. Journal in Which the research was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Leopoldo Segal, MD, director of the Lung Microbiome Program, …
Dexamethasone use could reduce immune checkpoint inhibitor viability in glioblastoma patients Kumar Jeetendra | November 25, 2020 Bottom Line: One of patients with glioblastoma getting an immune checkpoint inhibitor, people who obtained the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival. Journal Where the Study was Released: Clinical Cancer Research, a journal of the American Association for Cancer Research Author: David A. Reardon, MD, clinical director of the …
Researchers distinguish systems behind inflammasome initiation by fungal pathogens Kumar Jeetendra | December 3, 2020 Researchers at St. Jude Children’s Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, is a leading cause of infection-associated deaths in people with compromised immune systems. The work provides clues to a potential therapeutic approach for treating infectious and …
Researchers locate mechanism underlying plasticity in grownup brains Kumar Jeetendra | December 27, 2020 Developing brains continuously sprout new neuronal connections called synapses as they understand and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while links deemed unnecessary are pruned away. Adult brains experience similar pruning, but it was unclear why or how synapses in …
Enormous transporter protein dysfunction related with schizophrenia Kumar Jeetendra | December 29, 2020 Researchers have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it hard to show this and to pinpoint how it happens. Currently, Kazumitsu Ueda of Kyoto University’s Institute for Integrated Cell-Material Sciences (iCeMS) and colleagues in Japan have provided evidence that mice with disrupted ABCA13 protein demonstrate …
Gene therapy can viably treat mice with tuberous sclerosis complex, shows study Kumar Jeetendra | January 9, 2021 Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in several organs of the body, have limited treatment choices. A team led by investigators at Massachusetts General Hospital (MGH) has shown that gene therapy can effectively treat mice that express one of the mutated genes that cause the disease. …
Inflammation may add to the determination of C. diff disease, shows study Kumar Jeetendra | January 19, 2021 A new study from North Carolina State University indicates that the inflammation brought on by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and supplying nutrients that enable C. diff to thrive. C. diff is a bacterium that causes diarrhea, often with severe …
Immunotherapy treatments for nephrological autoimmune illnesses may help treat serious Coronavirus Kumar Jeetendra | June 8, 2021 Various viruses and bacteria have been known to cause autoimmune diseases where there’s such a predisposition. This phenomenon also seems to play a major part SARS-CoV-2, especially in severe courses. The body’s own immune cells are activated, with the formation of autoantibodies that attack the body’s own healthy cell structures (proteins, autoantigens); deposits of immune …
