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    MicroRNA

    Study: Anti-microRNA sedate essentially lessens miR-92a levels in human peripheral blood

    A single intravenous dose of MRG-110, an anti-microRNA drug, significantly reduced miR-92a levels from the blood of healthy humans. “According to documented, promising therapeutic possible, locked nucleic acid (LNA)-based anti-miR-92a was further developed and tested in a first in human analysis,” said Stefanie Dimmeler, PhD, Goethe University, Frankfurt, Germany and coauthors. “MRG-110 caused de-repression of

    Pancreatic β cell-inferred exosomal miR-29s control glucose homeostasis

    In a new study published in Journal of Extracellular Vesicles, Chen-Yu Zhang’s team at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig’s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in reaction to high levels of free fatty acids (FFAs). Formerly, Chen-Yu Zhang’s team identified