Analysts recognize anticoagulation operator that stifles SARS-CoV-2 replication in vitro Kumar Jeetendra | July 27, 2020 Effective antivirals with secure clinical profile are urgently needed to improve the overall prognosis. In an analysis of a randomly collected cohort of 124 patients using COVID-19, the authors discovered that hypercoagulability according to elevated levels of D-dimers was associated with illness severity. By calculating of a U.S. FDA approved drug library, the authors identified …
CARE consortium dispatches to quicken drug discovery and improvement for COVID-19 Kumar Jeetendra | August 19, 2020 Using a grant approximately $77.7 million, CARE is funded by cash donations by the European Union (EU) and money and in-kind contributions from Australian European Federation of Pharmaceutical Industries and Associations (EFPIA) businesses and three IMI-Associated Partners. CARE is a five-year project bringing together 37 partners from Belgium, China, Denmark, France, Germany, the Netherlands, Poland, …
First enzyme driven biocatalytic creation of nucleic acid structure blocks Kumar Jeetendra | December 15, 2020 Researchers in TU Graz and acib succeed in the first enzyme-driven biocatalytic synthesis of lipoic acid building blocks. This facilitates the development of antiviral agents and RNA-based therapeutics. Because of this COVID 19 pandemic and the related intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is undergoing an enormous increase in …
Poisonous pesticide transformed into treatment against antibiotic-resistant bacteria Kumar Jeetendra | December 30, 2020 They are used as pesticides and fungicides. However, these substances could be poisonous to humans and cause mutations. As they aren’t frequently used, there’s little data about them in the medicinal chemistry literature. However, it has been suggested recently that the groups of substances that are traditionally avoided can help to fight pathogenic bacteria. Yet, …
Compounds in green and black tea relax blood vessels by activating ion channel proteins Kumar Jeetendra | March 9, 2021 A new study from the University of California, Irvine shows that chemicals in both black and green tea relax blood vessels by activating ion channel proteins in the blood vessel wall. The discovery helps explain the antihypertensive properties of tea and could lead to the design of new blood pressure-lowering medications. Released in Cellular Physiology …
Drug-discovery collaboration discovers potential new antimalarial drug candidates Kumar Jeetendra | April 23, 2021 Potential new antimalarial drug candidates are being developed through an protracted drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation. A collaborative research team discovered compounds with antimalarial activity within a collection of 80,000 drug-like molecules at the Janssen Jump-stARter Compound Library, a …
