Gene therapy can viably treat mice with tuberous sclerosis complex, shows study Kumar Jeetendra | January 9, 2021 Patients with tuberous sclerosis complex, a genetic disorder characterized by the growth of noncancerous tumors in several organs of the body, have limited treatment choices. A team led by investigators at Massachusetts General Hospital (MGH) has shown that gene therapy can effectively treat mice that express one of the mutated genes that cause the disease. …
Researchers arrive at significant achievement in leishmaniasis immunization advancement Kumar Jeetendra | January 11, 2021 Scientists have taken an important step forward in creating a controlled human infection model to test leishmaniasis vaccines. The University of York-led study identified and characterized a new strain of Leishmania parasite that will form the basis of a new controlled human infection model for the disease which is transmitted by the bite of sand …
Study shows distancing and mandatory masks can forestall 87% of grounds COVID-19 diseases Kumar Jeetendra | January 13, 2021 The combined effectiveness of three COVID-prevention strategies on college campuses–mask-wearing, social distancing, and routine testing–are equally as effective in preventing coronavirus infections as the Pfizer and Moderna vaccines approved by the U.S. Food and Drug Administration (FDA), according to a new study co-authored by a Case Western Reserve University researcher. The study, published in Annals …
Daily aspirin can lessen danger of colorectal disease in adults Kumar Jeetendra | January 22, 2021 Regular aspirin use has clear benefits in reducing colorectal cancer incidence among middle-aged adults, but also comes with some risk, such as gastrointestinal bleeding. And when should adults start taking regular aspirin and for how long? There is substantial evidence that a daily aspirin can reduce risk of colorectal cancer in adults up to age …
New gene based vaccine procedure gets award from the Bill and Melinda Gates Foundation Kumar Jeetendra | January 29, 2021 The AAVCOVID vaccine application, a novel gene-based vaccine plan that utilizes an adeno-associated virus (AAV) vector, was granted an award for up to $2.1 million from the Bill & Melinda Gates Foundation. The grant will assist the effort to bring further preclinical validation into the AAV vaccine platform. An AAVCOVID vaccine candidate is set to …
Research investigate how the current practice of nephrology may have bigoted philosophies Kumar Jeetendra | January 31, 2021 There is a growing awareness of systematic inequality and structural racism in American society. Science and medicine are no exception, as evidenced by historical cases of discrimination and overt racism. In a perspective piece in the Journal of the American Society of Nephrology, researchers from Boston University School of Medicine (BUSM), take an honest look …
Study discoveries help clarify the variety of cancers in various Li-Fraumeni patients Kumar Jeetendra | February 23, 2021 The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several kinds of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations. Recent studies suggest that some people with inherited p53 …
Killing antibodies actuated by COVID-19 vaccines less successful against new variants Kumar Jeetendra | March 15, 2021 SARS-CoV-2, the virus that causes COVID-19, has mutated through the pandemic. New variants of this virus have arisen around the world, including variants that might possess increased capacity to spread or evade the immune system. Such variations have been identified in California, Denmark, the U.K., South Africa and Brazil/Japan. Recognizing how well the COVID-19 vaccines …
Scientists use genetics to recognize likely drugs for early administration of COVID-19 Kumar Jeetendra | April 12, 2021 A new study using human genetics indicates researchers should prioritize clinical trials of drugs that target two proteins to manage COVID-19 in its early stages. The findings appeared online in the journal Nature Medicine at March 2021. The purpose is to identify present drugs, either FDA-approved or in clinical development for other conditions, that can …
Study recognizes specific immune cells that shape inhibitory neurons to control mind wiring Kumar Jeetendra | July 7, 2021 Every second our brains are exposed to a variety of signals, from the barking of a puppy to raindrops hitting the windows, and everything in between. Most of the time we ignore insignificant cues like the buzzing of a fly or the gentle rustle of leaves in a tree. We pay attention to the more …
Study uncovers the complex cell mechanism of Ebola Kumar Jeetendra | July 8, 2021 Mount Sinai researchers discovered the intricate cellular mechanisms of Ebola virus. This could help to explain the severe effects on people and provide potential treatment or prevention. The team published a study in mBio that showed how VP24, a protein from the Ebola virus interacts with the double-layered cell membrane (known as the nucleus) and …
Analysts study the role of subnuclear NSrp70 in T cell-intervened adaptive immunity Kumar Jeetendra | July 15, 2021 T cell are part of the body’s immune response. The way proteins are spliced in their development and maturation determines how T cells can recognize different pathogens and mount defense against them. Scientists from Korea now highlight the role of NSrp70 in regulating maturation. This protein was previously found in T cells subnuclear space and …
