Genotype vs Phenotype: 8 key differences Kumar Jeetendra | March 31, 2023 The genetic make-up of a single cell or organism, known as its genotype, affects or influences its phenotype. The phrases genotype and phenotype, which contrast, are used to describe an organism’s traits. Here are some key differences between genotype and phenotype: Definition: The term “genotype” is used to describe an organism’s genetic make-up, while the term …