Novel nanospectroscopy measures biomolecular changes induced by drugs in human cells Kumar Jeetendra | July 20, 2020 Synchrotron InfraRed Nanospectroscopy has been used for the first time to measure biomolecular changes caused by a drug (amiodarone) in human cells (macrophages) and localized at 100 nanometre scale, i.e. two orders of magnitude smaller than the IR wavelength used as probe. This was achieved at the Multimode InfraRed Imaging and Micro-Spectroscopy (MIRIAM) beamline (B22) …
Biomedical scientists make counterfeit organelles to control biological function in cells Kumar Jeetendra | August 7, 2020 Biomedical engineers at Duke University have shown a way of controlling the phase separation of an emerging class of proteins to create artificial membrane-less organelles in human cells. The progress, similar to controlling how vinegar forms droplets within oil, creates chances for engineering artificial structures to modulate present cell functions or produce entirely new behaviours …
Analysts recognize interface among ALS and collection of DNA-RNA hybrids in the genome Kumar Jeetendra | January 13, 2021 Researchers from the University of Seville and the University of Pavia have identified a connection between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of …
Study shows why children of obese moms have inclination to create metabolic illnesses Kumar Jeetendra | January 27, 2021 A Brazilian study published in the journal Molecular Human Reproduction helps understand why overweight mothers often have children with a propensity to develop metabolic disease during their lifetime, according to previous research. According to the authors,”transgenerational transmission of metabolic disorders” may be associated with Mfn2 deficiency in the mother’s oocytes (immature eggs). Mfn2 refers to …
Scientists test a library of lipid-based compounds to empower safe RNA drug delivery to Lungs Kumar Jeetendra | July 30, 2021 Japan’s Hokkaido University researchers created and tested a collection of lipid-based compounds in order to deliver RNA drugs safely and effectively to the lungs. The findings were published in Materials Horizons. The COVID-19 pandemic response made it all more familiar with RNA vaccines. These vaccines carry genetic code into the cells, which triggers the production …
Small molecule drug can weaken the triggers of neuroinflammation, preclinical review shows Kumar Jeetendra | September 24, 2021 Neuroinflammation may cause worse outcomes in cases of stroke, injuries to the brain or injury, and can increase the severity of neurodegenerative diseases such as ALS, Parkinson’s, or Alzheimer’s. This suggests that reducing neuroinflammation might be an exciting new method to treat neurological disorders and neuropathic pain caused by neuroinflammation. In a preclinical study , …
