CRISPR-based framework smothers qualities identified with AAV antibody production Kumar Jeetendra | September 9, 2020 Gene therapy generally is based on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the event of CRISPR-based gene therapies, molecular scissors can then snip out a faulty gene, add in a missing arrangement or enact a temporary change in its expression, but the body’s immune response to AAV can …
PC model disentangles puzzle behind serious aggravation in individuals with COVID-19 Kumar Jeetendra | September 29, 2020 A study from the University of Pittsburgh School of Medicine and Cedars-Sinai addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation? The research shows how the molecular arrangement and arrangement of the SARS-CoV-2 spike protein–part of the virus that causes COVID-19–could be behind the inflammatory syndrome cropping up …
CBD could lessen lung harm brought about by COVID-19 Kumar Jeetendra | October 19, 2020 One way CBD appears to reduce the”cytokine storm” that damages the lungs and kills many individuals with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is proven to reduce inflammation and whose levels are dramatically reduced in the face of this storm. Dental College of Georgia and Medical …
Microorganisms in the lungs could impact lung cancer progression and prognosis Kumar Jeetendra | November 11, 2020 Bottom Line: Enrichment of the lungs with oral commensal microbes has been correlated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer. Journal in Which the research was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Leopoldo Segal, MD, director of the Lung Microbiome Program, …
Study uncovers immune defense system that shields the lungs from viral diseases Kumar Jeetendra | March 18, 2021 Scientists have discovered a previously unknown arm of the immune defense system that protects the lung from lethal viral infections. Respiratory diseases caused by viruses such as influenza A and SARS-CoV-2 cause harm not only through their own activities, but also from collateral damage as the immune system reacts to combat the infection. A timely …
Intense openness of lung tissue to vape airborne lesserly affects gene expressionthan cigarette smoke Kumar Jeetendra | March 21, 2021 A new peer-reviewed study published in the journal Toxicological Research & Application reveals acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression in contrast to smoke from combustible cigarettes. The study included sub-cytotoxic vulnerability to cells in a 3D human bronchial model (MucilAirTM) to nicotine-containing vape …
Small molecule drug can weaken the triggers of neuroinflammation, preclinical review shows Kumar Jeetendra | September 24, 2021 Neuroinflammation may cause worse outcomes in cases of stroke, injuries to the brain or injury, and can increase the severity of neurodegenerative diseases such as ALS, Parkinson’s, or Alzheimer’s. This suggests that reducing neuroinflammation might be an exciting new method to treat neurological disorders and neuropathic pain caused by neuroinflammation. In a preclinical study , …