Myeloid cells can smother insusceptible reaction, advance cerebrum metastasis Kumar Jeetendra | October 28, 2020 Scientists have long thought that the brain protects itself from an aggressive immune response to keep inflammation down. However, that evolutionary management may work against it when a cancer cell tries to spread to the brain, researchers at the University of Notre Dame have found. In recently published research in the journal Cell, researchers showed …
SARS-CoV-2 hereditary changes may have made COVID-19 more infectious Kumar Jeetendra | October 31, 2020 A study involving over 5,000 COVID-19 patients in Houston finds the virus which causes the disease is accumulating genetic mutations, one of which may have made it longer infectious. According to the paper published in the peer reviewed journal mBIO, that mutation, known as D614G, is found in the spike protein that pries open our …
Drug used to control pulse may improve malignant growth patients’ reaction to immunotherapy Kumar Jeetendra | November 1, 2020 The exact same biochemical triggers which spur a”flight or fight” reaction once we encounter threats may help tumor cells to thrive. A group of researchers from Roswell Park Comprehensive Cancer Center is looking at ways to interrupt that dynamic so that cancer therapies can be effective. Their latest work, published today in Clinical Cancer Research, …
Improving affectability of fluid biopsy utilizing ‘inexactly stacked’ identification layers Kumar Jeetendra | November 4, 2020 By detecting DNA fragments in body fluids like urine, some kinds of cancer may already be tracked in an early stage. But in order to capture them, detection sensitivity must be improved. Researchers at the University of Twente in The Netherlands (MESA+ Institute) use electrically charged polymers for this. Not only one layer of this, …
Microorganisms in the lungs could impact lung cancer progression and prognosis Kumar Jeetendra | November 11, 2020 Bottom Line: Enrichment of the lungs with oral commensal microbes has been correlated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer. Journal in Which the research was Published: Cancer Discovery, a journal of the American Association for Cancer Research Author: Leopoldo Segal, MD, director of the Lung Microbiome Program, …
Patients’ own stem cells can be utilized to develop new bones, study shows Kumar Jeetendra | November 23, 2020 A new, groundbreaking study from the University of Bergen (UiB) shows that a patients’ own stem cells can be used to grow new bone. This can potentially help millions of people who are partially edentulous and have inadequate bone for placement of dental implants. The Maxibone Project, coordinated by Pierre Layrolle, Inserm, University of Nantes, …
Dexamethasone use could reduce immune checkpoint inhibitor viability in glioblastoma patients Kumar Jeetendra | November 25, 2020 Bottom Line: One of patients with glioblastoma getting an immune checkpoint inhibitor, people who obtained the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival. Journal Where the Study was Released: Clinical Cancer Research, a journal of the American Association for Cancer Research Author: David A. Reardon, MD, clinical director of the …
Researchers grow first plant-based gel to help organoid development for biomedical applications Kumar Jeetendra | November 26, 2020 Monash University researchers have created the world’s first bioactive plant-based nanocellulose hydrogel to support organoid growth and help significantly reduce the costs of research into cancer and COVID-19. This discovery by researchers in BioPRIA (Bioresource Processing Institute of Australia), Monash University’s Department of Chemical Engineering and the Monash Biomedicine Discovery Institute will develop organoids cheaper, …
Researchers utilize human stem cells and bioengineered platform to construct entire working thymus Kumar Jeetendra | December 11, 2020 Their work is an important step towards having the ability to build artificial thymi that could be utilised as transplants. The thymus is an organ in the chest where T lymphocytes, which play a vital role in the immune system, mature. If the thymus doesn’t work properly or doesn’t form during foetal development in the …
Hematoxylin compounds can specifically kill CALR mutant cancer cells Kumar Jeetendra | December 11, 2020 Patients with myeloproliferative neoplasm (MPN), a group of malignant diseases of the bone marrow, often have a carcinogenic mutated form of the calreticulin gene (CALR). Researchers of the research team of Robert Kralovics, Adjunct Principal Investigator in the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and team leader at the …
IGC analysts get three out of six European Research Council grants Kumar Jeetendra | December 11, 2020 Since the establishment of the European Research Council in 2008, the IGC has secured 17 of the competitive grants (7 Beginning, 8 Consolidator and two Advanced). In 2021, with the beginning of the new grants awarded this month, it will have ten active grants. The year of 2020 marks a total of 327 researchers chosen …
new cGMP plasmid DNA manufacturing facility construction announced by Thermo Fisher Kumar Jeetendra | December 18, 2020 Thermo Fisher Scientific, the world leader in serving science, today announced the construction of a new cGMP plasmid DNA manufacturing facility in Carlsbad, Calif. The site will expand the company’s clinical and commercial capabilities for cGMP plasmid DNA used as a critical raw material to develop and manufacture cell and gene-based therapies including life-saving cancer …
